(3S,12S)-1-((S)-1-((6S,12S,15S,21S,30S)-1-((S)-1-(2-acetamido-2-methylpropanoyl)pyrrolidin-2-yl)-15-(3-amino-3-oxopropyl)-30-isobutyl-21-isopropyl-3,3,6,9,9,12,18,18,24,24,33,33-dodecamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaoxo-2,5,8,11,14,17,20,23,26, (3S,12S)-1-((S)-1-((6S,12S,15S,15S,21S,30S)-1-((S)-1-((S)-1-(2-乙酰氨基-2-乙酰氨基-2-甲基丙酰基)吡咯烷基-2-基)-15-(3-氨基-3-氧代丙基)-30-异丙基-3,3,3,3,3,3,6,9,9,9,9,12,18,18,18,24,24,24,33,33,33,33,33,33-十二甲基-1,4,4,7,7,7,10,13,13,16,16,19,22,25,25,28,28,31-十一氧氧-2,5,5,8,8,11,11,11,

CAS 27061-78-5 MFCD00151517

化学结构图

27061-78-5
SMILES: CC(=O)NC(C)(C)C(=O)N1CCC[C@H]1C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(C)C(=O)N[C@@H](C(C)C)C(=O)NC(C)(C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)CO

化学属性

Mol. FormulaC92
Mol. Weight1964

别名和识别编码

Chemical Name(3S,12S)-1-((S)-1-((6S,12S,15S,21S,30S)-1-((S)-1-(2-acetamido-2-methylpropanoyl)pyrrolidin-2-yl)-15-(3-amino-3-oxopropyl)-30-isobutyl-21-isopropyl-3,3,6,9,9,12,18,18,24,24,33,33-dodecamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaoxo-2,5,8,11,14,17,20,23,26,
Synonym
MDL NumberMFCD00151517
PubChem Substance ID24890893
Beilstein Registry Number5213858
CAS Number27061-78-5
Chemical Name Translation(3S,12S)-1-((S)-1-((6S,12S,15S,15S,21S,30S)-1-((S)-1-((S)-1-(2-乙酰氨基-2-乙酰氨基-2-甲基丙酰基)吡咯烷基-2-基)-15-(3-氨基-3-氧代丙基)-30-异丙基-3,3,3,3,3,3,6,9,9,9,9,12,18,18,18,24,24,24,33,33,33,33,33,33-十二甲基-1,4,4,7,7,7,10,13,13,16,16,19,22,25,25,28,28,31-十一氧氧-2,5,5,8,8,11,11,11,
InChIKeyLGHSQOCGTJHDIL-UTXLBGCNSA-N
EC Number200-664-3
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分类

  • A-AM, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Interferes with Cell Membrane Permeability (Ionophores), Ion Channels, Ionophores, Mechanism of Action, Monovalent Ion Channels, Voltage-gated Ion Channels
  • {SNA} A-AM, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
  • {SNA} A-AM,

相关文献及参考

  • Cosette, P., et al., The ion-channel activity of longibrachins LGA I and LGB II: effects of Pro-2/Ala and Gln-18/Glu substitutions on the alamethicin voltage-gated membrane channels. Biochim. Biophys. Acta 1461 , 113-122, (1999) 摘要
  • Duclohier, H., et al., C-terminally shortened alamethicin on templates: influence of the linkers on conductances. Biochim. Biophys. Acta 1420 , 14-22, (1999) 摘要
  • Tieleman, D.P., et al., Surface binding of alamethicin stabilizes its helical structure: molecular dynamics simulations. Biophys. J. 76 , 3186-3191, (1999) 摘要
  • Kruglov, A.G., et al., Novel Mycotoxin From Acremonium Exuviarum Is A Powerful Inhibitor Of The Mitochondrial Respiratory Chain Complex III. Chem. Res. Toxicol. 22 , 565-73, (2009) 摘要
  • Ye, S., et al., Observing a model ion channel gating action in model cell membranes in real time in situ: membrane potential change induced alamethicin orientation change J. Am. Chem. Soc. 134 , 6237-43, (2012)
  • Bechinger, B. and Salnikov, E.S., The membrane interactions of antimicrobial peptides revealed by solid-state NMR spectroscopy Chem. Phys. Lipids 165 , 282-301, (2012)
  • Stava, E., et al., On-Chip Stochastic Resonance of Ion Channel Systems With Variable Internal Noise IEEE Trans. Nanobioscience 11(2) , 169-75, (2012)

安全信息

Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
WGK Germany3
GHS Symbol
Precautionary statements
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
Hazard Codes T
Signal word
Packing GroupIII
Safety Statements
Risk Statements
UN Number

系列性分类

  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics A-F - Antibiotics A to Z
  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Mechanism of Action - Antibiotics
  4. Interferes with Cell Membrane Permeability (Ionophores) - Mechanism of Action
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Ion Channels - Cell Signaling and Neuroscience
  5. Voltage-gated Ion Channels - Ion Channels
  6. Monovalent Ion Channels - Voltage-gated Ion Channels
  7. Ionophores - Monovalent Ion Channels

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