5-(N-Ethyl-N-isopropyl)amiloride 5-(N-乙基-N-异丙基)阿米洛利
CAS 1154-25-2 MFCD00151710
化学结构图
SMILES: CCN(c1nc(N)c(C(=O)NC(=N)N)nc1Cl)C(C)C
化学属性
| Mol. Formula | C11 H18 Cl N7 O |
|---|---|
| Mol. Weight | 299.76 |
| Melting Point | 198-200°C |
| Boiling Point |
别名和识别编码
| Chemical Name | 5-(N-Ethyl-N-isopropyl)amiloride |
|---|---|
| CAS Number | 1154-25-2 |
| Synonym | 3-Amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]- 5-(N-Ethyl-N-isopropyl) Amiloride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {SNA} EIP |
| MDL Number | MFCD00151710 |
| PubChem Substance ID | 1795 |
| Chemical Name Translation | 5-(N-乙基-N-异丙基)阿米洛利 |
| InChI | InChI=1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20) |
| LabNetwork Molecule ID | LN01307789 |
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分类
- Bases & Related Reagents
- {SNA} A to C, Adenosinetriphosphatase (Na/K), Amiloride and Derivatives, Biochemicals and Reagents, E, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Ion Channels, Monovalent Ion Channels, Sodium Channel Modulators, Voltage-gated Ion Channels, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- Nucleotides
- Inhibitors
- {SNA} A to C, Adenosinetriphosphatase (Na/K), Amiloride and Derivatives, Bioactive Small Molecule Alphabetical Index, E, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Ion Channels, Monovalent Ion Channels,
产品应用
- Selective Na+/H+ antiporter inhibitor. Selectively enhances the excretion of sodium ions without causing an increase in excretion of potassium ions.
相关文献及参考
- Gupta, et al.: J. Pharmacol. Exp. Ther., 248(3), 991 (1989)
- Abrahamse, S.L., et al. Am. J. Physiol. 267 , G409, (1994) 摘要
- Watts III, B.A., Good, D.W. J. Biol. Chem. 269 , 20250, (1994) 摘要
- Heikkila, O., et al., Internalization of Coxsackievirus A9 Is Mediated by {beta}2-Microglobulin, Dynamin, and Arf6 but Not by Caveolin-1 or Clathrin J. Virol. 84 , 3666-81, (2010) 摘要
- Heikkilä, O., et al., Internalization Of Coxsackievirus A9 Is Mediated By β2-Microglobulin, Dynamin, And Arf6 But Not By Caveolin-1 Or Clathrin J. Virol. 84 , 3666-3681, (2010) 摘要
- Faul, E.J., et al., Rabies Virus Infection Induces Type I Interferon Production In An IPS-1 Dependent Manner While Dendritic Cell Activation Relies On IFNAR Signaling. PLoS Pathog. 6 , e1001016, (2010) 摘要
- Maxwell, C.R., et al., Acetate Causes Alcohol Hangover Headache In Rats. PLoS ONE 5 , e15963, (2010) 摘要
- Erdogan, S., et al., Changes In The Activity Of Defense Mechanisms Against Induced Acidosis During Meiotic Maturation In Mouse Oocytes. Theriogenology 75 , 1057-66, (2011) 摘要
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
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