DESLORELIN

CAS 57773-65-6 MFCD00167401

化学结构图

57773-65-6
SMILES: CC(C)C[C@H](NC(=O)[C@@H](CC1=CNC2C=CC=CC=21)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CNC2C=CC=CC=21)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NCC

化学属性

Mol. FormulaC64H83N17O12
Mol. Weight1282.45

别名和识别编码

Chemical Name[des-Gly10, D-Trp6]-LH-RH ethylamide
Synonym Bachem 9022 (D-Trp(sup 6)-pro(sup 9))-luteinizing hormone-releasing hormone Deslorelin D-Trp(sup 6)-pro(sup 9)-N-ethylamide-LHRH Somagard Gonadotropin releasing hormone, (D-trp(sup 6)-pro(sup 9)-NEt)- (D-Trp(sup 6)-pro(sup 9))-LHRH ethylamide (D-Trp(sub 6)-pro(sup 9)-NEt)-GNRH
MDL NumberMFCD00167401
CAS Number57773-65-6
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分类

  • Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, L, LH-RH, Neuropeptides, Peptides and Proteins, Peptides for Cell Biology, Releasing Factors
  • {SNA} LH-RH, Neuropeptides, Peptides and Proteins, Peptides for Cell Biology, Releasing Factors, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, L, LH-RH, Neuropeptides, Peptides and Proteins, Peptides for Cell Biology, Releasing Factors

相关文献及参考

  • Krsmanovic, L.Z., et al., Autocrine regulation of gonadotropin-releasing hormone secretion in cultured hypothalamic neurons. Endocrinology 140 , 1423-1431, (1999) 摘要
  • Naqvi, R.H., and Lindberg, M.C., Biopharmaceutic stability of [D-Trp 6 , des-Gly 10 ]-LHRH ethyl amide in corn oil. Endocrinol. Res. 11 , 139-144, (1985)
  • Merck 14 ,2923

安全信息

GHS Symbol
WGK Germany3
Precautionary statements
  • P308+P313
  • P201 Obtain special instructions before use. 使用前获取专门指示。
Signal word Danger
Hazard statements
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
Hazard Codes T
RTECSOK6755000
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges 
TYPE OF TEST            : TDLo - Low

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Human - man
DOSE                    : 30 ug/kg
SEX/DURATION            : male 42 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - sperm

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Primate - monkey
DOSE                    : 150 ug/kg
SEX/DURATION            : female 75 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
   INJFA3 International Journal of Fertility.  (Allen Press, 1041 New
   Hampshire,  St., Lawrence, KS 66044)  V.1-    1955- Volume(issue)/page/year:
   25,171,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 28 ng/kg
SEX/DURATION            : male 7 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   ENDOAO Endocrinology (Baltimore).  (Williams & Wilkins Co., 428 E. Preston
   St., Baltimore, MD 21203) V.1-    1917-  Volume(issue)/page/year:
   105,1191,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 15 ug/kg
SEX/DURATION            : female 5-7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
   ENDOAO Endocrinology (Baltimore).  (Williams & Wilkins Co., 428 E. Preston
   St., Baltimore, MD 21203) V.1-    1917-  Volume(issue)/page/year:
   103,2299,1978

TYPE OF TEST

Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S22 Do not breathe dust 不要吸入粉尘；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
Risk Statements
  • R60 May impair fertility 可能降低生殖能力

系列性分类

  1. Neuropeptides - Peptides for Cell Biology
  2. Releasing Factors - Neuropeptides
  3. LH-RH - Releasing Factors
  1. Releasing Factors - Peptides for Cell Biology
  2. LH-RH - Releasing Factors
  1. Releasing Factors - Peptides for Cell Biology
  2. LH-RH - Releasing Factors

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