Pholedrine 对羟基甲基苯丙胺

CAS 370-14-9 MFCD00178702

化学结构图

370-14-9
SMILES: CNC(C)Cc1ccc(O)cc1

化学属性

Mol. FormulaC10H15NO
Mol. Weight165.26

别名和识别编码

Chemical Namep-Hydroxymethamphetamine
CAS Number370-14-9
Synonym ######## 1-(p-Hydroxyphenyl)-2-methylaminopropane 1-(p-Oxyphenyl)-2-methylaminopropan 4-hydroxy-N-methylamphetamine 4-hydroxymethamphetamine Epifen Foledrin Isodrine Isodrinum Knoll H75 N-Methylparedrine Paredrinol Phenethylamine, p-hydroxy-N,alpha-dimethyl- Pholedrin liquidum Pholedrin-longo-Isis Pholedrine Pholetone Pressitan Promethin Prometin Pulsotyl Stimatone Sympropamin Syncordan Terapinyl Varitol Veritain Veritol alpha-(p-Hydroxyphenyl)-beta-methylaminopropane alpha-(p-Oxyphenyl)-beta-methyl aminopropane beta(p-Oxy-phenyl)isopropylmethylamin beta-(p-Hydroxyp
MDL NumberMFCD00178702
PubChem Substance ID4655
EC Number206-725-0
Wiswesser Line NotationQR D1Y1&M1
Chemical Name Translation对羟基甲基苯丙胺
InChIInChI=1S/C10H15NO/c1-8(11-2)7-9-3-5-10(12)6-4-9/h3-6,8,11-12H,7H2,1-2H3
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分类

  • Aromatics
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • {SNA} Alphabetic, Amphetamine, Analytical Standards, Analytical/Chromatography, Chemical Structure, Chromatography, Drugs & Metabolites, Drugs of Abuse, Forensic and Veterinary Standards, H, HU - HZ, Neat Compounds

相关文献及参考

  • Glennon, R., et al.: J. Med. Chem., 23, 294 (1980),
  • de Letter, E., et al.: J. Anal. Toxicol., 26, 113 (2002),
  • Lin, D., et al.: J. Anal. Toxicol., 31, 109 (2007),

安全信息

GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P332+P317
  • P337+P317
  • P362+P364
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
WGK Germany3
Signal word Warning
RTECSSL8400000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
Hazard Codes Xi
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Restrict 精神药品
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 119 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 3,328,1953

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in psychophysiological tests
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 159,442,1966

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme
   Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948
    Volume(issue)/page/year: -,101,1948

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 195,647,1940

系列性分类


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