Oxandrolone 氧甲氢龙

CAS 53-39-4 MFCD00198944

化学结构图

53-39-4
SMILES: C[C@]12COC(=O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(C)O

化学属性

Mol. FormulaC19H30O3
Mol. Weight306.44
Melting Point235-238 ºC

别名和识别编码

Chemical NameOxandrolone
CAS Number53-39-4
Synonym (5?,17?)-17-Hydroxy-17-methyl-2-oxaandrostan-3-one 17-Methyl-2-oxa-5?-androstan-17?-ol-3-one 17-beta-hydroxy-17-methyl-2-oxa-5-alpha-androstan-3-on 17-beta-hydroxy-17-methyl-2-oxa-androstan-3-one 17-hydroxy-17-methyl-,(5-alpha,17-beta)-2-oxaandrostan-3-on 17-hydroxy-17-methyl-,(5alpha,17beta)-2-oxaandrostan-3-on 17?-Hydroxy-17-methyl-2-oxa-5?-androstan-3-one 17BETA-HYDROXY-17-METHYL-2-OXA-5ALPHA-ANDROSTAN-3-ONE 17beta-Hydroxy-17-methyl-2-oxa-5alpha-androstan-3-one 17beta-Hydroxy-17alpha-methyl-2-oxa-5alpha-androstan-3-one 17beta-hydroxy-17-methyl-2-oxa-5alpha-androstan-3-on 17β-Hydroxy-17α-methyl-2-oxa-5α-androstan-3-one 8075CB NSC 67068 Oxandren Provitar SC 11585 Vasorome 1H-Benz(e)indene-7-acetic acid, dodecahydro-3-hydroxy-6-(hydroxymethyl)-3,3a,6-trimethyl-, delta-lactone 2-Oxa
EC Number200-172-9
MDL NumberMFCD00198944
Chemical Name Translation氧甲氢龙
Merck Number6921
Wiswesser Line NotationT E5 B666 OVOTJ A1 E1 FQ F1
PubChem Substance ID5878
InChIInChI=1S/C19H30O3/c1-17-11-22-16(20)10-12(17)4-5-13-14(17)6-8-18(2)15(13)7-9-19(18,3)21/h12-15,21H,4-11H2,1-3H3/t12-,13+,14-,15-,17-,18-,19-/m0/s1
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分类

  • Pharmaceuticals
  • {SNA} Androgen, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, New Products, Steroid Hormones
  • Steroids,
  • Intermediates & Fine Chemicals
  • {SNA} Androgen, Bioactive Small Molecule Alphabetical Index, Cytokines, Growth Factors and Hormones, Hormones, O, Steroid Hormones, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学

产品应用

  • A synthetic, anabolic steroid. Used to promote muscle growth and combat involuntary weight loss. It has also been used to treat cases of osteoporosis.

相关文献及参考

  • Cadwallader, A., et al.: Mol. Pharm., 7, 689 (2010),
  • Amundson, E., et al.: J. Clin. Endocrinol. Metabol., 95, 1355 (2010),
  • Bovee, T., et al.: J. Steroid Biochem. Mol. Biol., 118, 85 (2010),

安全信息

RTECSRN6800700
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1832 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - somnolence (gen

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,149,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 922 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   65,418,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   65,418,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcu

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 70 mg/kg
SEX/DURATION            : female 14 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 5,489,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 300 mg/kg
SEX/DURATION            : female 30 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   RPHRA6 Recent Progress In Hormone Research.  Proceedings of the Laurentian
   Hormone Conference. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
    V.1-    1947-  Volume(issue)/page/year: 20,395,1964

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1800 mg/kg
SEX/DURATION            : female 2-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Fertility - abortion
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 22,735,1971

GHS Symbol
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S22 Do not breathe dust 不要吸入粉尘;
Hazard Codes T
Risk Statements
  • R60 May impair fertility 可能降低生殖能力
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
WGK Germany3
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P302+P352
  • P304+P312
  • P304+P340
  • P308+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Hazard statements
  • H312 Harmful in contact with skin 皮肤接触有害
  • H332 Harmful if inhaled 吸入有害
  • H351 Suspected of causing cancer 怀疑致癌
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害

其他信息

  • 可燃性危险特性:可燃; 燃烧产生刺激烟雾
  • 储运特性:库房通风低温干燥
  • MOL 文件:53-39-4.mol
  • 毒性分级:中毒
  • Sigma Aldrich:53-39-4(sigmaaldrich)
  • 图谱信息:氧甲氢龙(53-39-4)核磁图( 13 CNMR) 氧甲氢龙(53-39-4)核磁图( 1 HNMR) 氧甲氢龙(53-39-4)质谱(MS)
  • 灭火剂:干粉、泡沫、砂土、二氧化碳,雾状水
  • 类别:有毒物品
  • 急性毒性:腹腔-大鼠LD50: 4893 毫克/公斤; 口服-小鼠LD50: 1832 毫克/公斤

系列性分类


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