(E)-N-Benzyl-2-Cyano-3-(3,4-Dihydroxyphenyl)Acrylamide (E)-N-苄基-2-氰基-3-(3,4-二羟苯基)丙烯酰胺
CAS 133550-30-8 MFCD00209833
化学结构图
SMILES: N#C/C(=C\c1ccc(O)c(O)c1)C(=O)NCc1ccccc1
化学属性
| Mol. Formula | C17H14N2O3 |
|---|---|
| Mol. Weight | 294.3 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | (E)-N-Benzyl-2-Cyano-3-(3,4-Dihydroxyphenyl)Acrylamide |
|---|---|
| Synonym | AG 490; AG490; AG-490; Tyrphostin AG 490 |
| Chemical Name Translation | (E)-N-苄基-2-氰基-3-(3,4-二羟苯基)丙烯酰胺 |
| Formula | C17H14N2O3 |
| IUPAC Name | (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide |
| InChIKey | TUCIOBMMDDOEMM-RIYZIHGNSA-N |
| InChI | InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+ |
| Canonical SMILES | O=C(NCC1=CC=CC=C1)/C(C#N)=C/C2=CC=C(O)C(O)=C2 |
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产品应用
- Tyrphostin AG490 is a JAK-2 specific inhibitor, which inhibits phosphorylation of EGFR and signal transducer and activator of transcription 3 [STAT-3], and subsequently reduce invasion and adhesion potential of malignant cells. The hematopoietic cancer c-Kit+, Jak-2+ and non hematopoietic tumors c-Kit+, HER-2+, JAK-2+ can be inhibited by the chemosensitizing agent AG490 causing programmed cell death.
安全信息
GHS Symbol
UN Number
Hazard Codes
Signal word
WGK Germany3
Safety Statements
Risk Statements
Precautionary statements
Packing GroupIII
Storage condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
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