6-(Trifluoromethoxy)-2-benzothiazolamine 2-氨基-6-三氟甲氧基苯并噻唑
CAS 1744-22-5 MFCD00210213
化学结构图
SMILES: Nc1nc2ccc(OC(F)(F)F)cc2s1
化学属性
| Mol. Formula | C8H5F3N2OS |
|---|---|
| Mol. Weight | 234 |
| Melting Point | 116.0 to 120.0 deg-C |
| TSCA | No |
| Solubility | DMSO 47 mg/mL Water <1 mg/mL Ethanol 47 mg/mL |
别名和识别编码
| Chemical Name | 6-(Trifluoromethoxy)-2-benzothiazolamine |
|---|---|
| CAS Number | 1744-22-5 |
| Alfabeta Name | AMINOTRIFLUOROMETHOXYBENZOTHIAZOLE 26()--- |
| MDL Number | MFCD00210213 |
| Synonym | 2 Amino 6 trifluoromethoxybenzothiazole 2-Amino-6-(trifluoromethoxy)benzothiazole; 6-Trifluoromethoxy-2-aminobenzothiazole; 6-(Trifluoromethoxy)-1,3-benzothiazol-2-amine 2-Amino-6-trifluoromethoxybenzothiazole 2-Benzothiazolamine, 6-(trifluoromethoxy)- 2-Amino-6-(trifluoromethoxy)benzothiazole 6-(Trifluoromethoxy)-2-benzothiazolamine 6-(Trifluoromethoxy)benzothiazol-2-amine Amino-2 trifluoromethoxy-6 benzothiazole PK 26124 PK-26124 PK26124 RP 54274 RP-54274 RP54274 Rilutek Riluzole 利鲁唑;2-氨基-6-(三氟甲氧基)苯并噻唑 |
| PubChem Substance ID | 5070 |
| Chemical Name Translation | 2-氨基-6-三氟甲氧基苯并噻唑 |
| Reaxys-RN | 748759 |
| Merck Number | 8223 |
| LabNetwork Molecule ID | LN00110713 |
| InChI | InChI=1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13) |
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分类
- Pharmaceuticals
- Inhibitors
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Excitatory Amino Acids, Neuroscience, Neurotransmission, Neurotransmitters, Other Excitatory Amino Acids, R, Sanofi Aventis, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- Sulfur & Selenium Compounds
- Heterocycles
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Signaling and Neuroscience, Excitatory Amino Acids, Neuroscience, Neurotransmission, Neurotransmitters, Others, R, Sanofi Aventis, 细胞生物学
- {SNA} Approved Therapeutics/Drug Candidates,
产品应用
- A neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant.
相关文献及参考
- Mizoule, J., et al.: Neuropharmacology, 24, 767 (1985),
安全信息
GHS Symbol
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P301+P310
- P301+P310+P330
- P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
- P330 Rinse mouth. 漱口
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H300 Fatal if swallowed 吞食致命
- H301 Toxic if swallowed 吞食有毒
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S20 When using do not eat or drink 使用时，不得进食，饮水；
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 67 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #50551
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 46 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #50551
其他信息
- Riluzole
- Riluzole用于治疗肌萎缩性侧索硬化症。
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