(S)-( )-3-Chloro-1,2-propanediol (S)-3-氯-1,2-丙二醇

CAS 60827-45-4 MFCD00210270

化学结构图

60827-45-4
SMILES: OC[C@H](O)CCl

化学属性

Mol. FormulaC{3}H{7}ClO{2}
Mol. Weight111
Refractive index1.4780 to 1.4820
Boiling Point213
Density1.322
Flash Point126°C(lit.)
TSCANo

别名和识别编码

Chemical Name(S)-( )-3-Chloro-1,2-propanediol
Synonym (S)-alpha-Chlorohydrin (S)-α-Glycerol chlorohydrin (S)-(+)-3-氯-1,2-丙二醇
CAS Number60827-45-4
PubChem Substance ID87566539
Beilstein Registry Number2202929
MDL NumberMFCD00210270
Reaxys-RN2202929
Chemical Name Translation(S)-3-氯-1,2-丙二醇
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分类

  • Asymmetric Synthesis, Chemical Synthesis, Chiral Building Blocks, Organic Building Blocks, Polyols
  • {SNA} Asymmetric Synthesis, Chemical Synthesis, Chiral Building Blocks, Organic Building Blocks, Polyols

产品应用

  • 1.药物中间体; 2.合成手性精细化学品中间体。

相关文献及参考

  • FT-IR 2 (1), 261:B / Structure Index 1 , 24:B:4

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H318 Causes serious eye damage 严重伤害眼睛
  • H312 Harmful in contact with skin 皮肤接触有害
  • H301 Toxic if swallowed 吞食有毒
  • H300 Fatal if swallowed 吞食致命
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes T
RTECSTY4202300
Precautionary statements
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P332+P313
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P308+P313
  • P302+P350
  • P301+P310
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P305+P351+P338+P310
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P304+P340+P312
  • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
  • P302+P352+P312+P361+P364
  • P301+P310+P330
Signal word
UN Number
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
  • R21 Harmful in contact with skin 与皮肤接触有害
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
  • R23/25 Toxic by inhalation and if swallowed 吸入及吞食都有毒
  • R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
  • R60 May impair fertility 可能降低生殖能力
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S20 When using do not eat or drink 使用时,不得进食,饮水;
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S4 Keep away from living quarters 远离生活区;
  • S9 Keep container in a well-ventilated place 保持容器在通风良好的场所;
Packing GroupIII
Hazard Class6.1
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 45500 ug/kg
SEX/DURATION            : male 14 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 51,105,1977

系列性分类


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