Ethyl 4-((6-Guanidinohexanoyl)Oxy)Benzoate Methanesulfonate 加贝酯甲磺酸盐

CAS 56974-61-9 MFCD00210299

化学结构图

56974-61-9
SMILES: CCOC(=O)C1C=CC(=CC=1)OC(=O)CCCCCNC(N)=N.CS(O)(=O)=O

化学属性

Mol. FormulaC17H27N3O7S
Mol. Weight417
Melting Point91

别名和识别编码

Chemical NameEthyl 4-((6-Guanidinohexanoyl)Oxy)Benzoate Methanesulfonate
Synonym 4-(6-胍基己酰氧基)苯甲酸乙酯甲磺酸盐 4-[[6-[(氨基亚氨基甲基)氨基]-1-氧己基]氧]苯甲酸乙酯 甲磺酸盐 福耶 Ethyl p-(6-guanidinohexanoyloxy) benzoate methanesulfonate FOY Gabexate Methanesulfonate Gabexate mesilate p-Hydroxybenzoic acid ethyl ester 6-guanidinohexanoate mesilate 甲磺酸加贝酯
MDL NumberMFCD00210299
Chemical Name Translation加贝酯甲磺酸盐
CAS Number56974-61-9
Reaxys-RN5702026
Merck Number4320
PubChem Substance ID253660880
Beilstein Registry Number5702026
Wiswesser Line NotationMUYZM5VOR DVO2 &WSQ1
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分类

  • {SNA} A to C,
  • {SNA} A to C, Additional Drugs, Additional Standards, Analytical Standards, Chemical Structure, Chromatography, Chymotrypsin, α-, Chymotrypsin, alpha-, Coagulation Proteins and Reagents, D to K, Drugs of Abuse, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Forensic and Veterinary Standards, Inhibitors, Kallikrein, Plasma, Others, P to Q, Pharmaceuticals, Illicit Drugs & Alcohol, Plasma & Blood Proteins, Plasmin, Protease Inhibitor Specificity Index, Protease Inhibitors, R to Z, Thrombin,

相关文献及参考

  • [2]. Aosasa, S., et al., Mechanism of the inhibitory effect of protease inhibitor on tumor necrosis factor alpha production of monocytes. Shock, 2001. 15(2): p. 101-5.
  • [3]. Colasanti, M., et al., Effect of gabexate mesylate (FOY), a drug for serine proteinase-mediated diseases, on the nitric oxide pathway. Biochem Biophys Res Commun, 1998. 246(2): p. 453-6.
  • [1]. Erba, F., et al., Selective inhibition of human mast cell tryptase by gabexate mesylate, an antiproteinase drug. Biochem Pharmacol, 2001. 61(3): p. 271-6.
  • [1]. Erba, F., et al., Selective inhibition of human mast cell tryptase by gabexate mesylate, an antiproteinase drug. Biochem Pharmacol, 2001. 61(3): p. 271-6.
  • [2]. Aosasa, S., et al., Mechanism of the inhibitory effect of protease inhibitor on tumor necrosis factor alpha production of monocytes. Shock, 2001. 15(2): p. 101-5.
  • [3]. Colasanti, M., et al., Effect of gabexate mesylate (FOY), a drug for serine proteinase-mediated

安全信息

RTECSDG2800800
WGK Germany2
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
GHS Symbol
UN Number 3077
Hazard Codes 9
Signal word Warning
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P301+P312
  • P330 Rinse mouth. 漱口
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Packing GroupIII 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 6480 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - changes in motor activity (specific assay)
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 9,743,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4020 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 9,743,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 8 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - changes in motor activity (specific assay)
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 9,743,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 79 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/p

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Forensic and Veterinary Standards - Chromatography
  5. Drugs & Metabolites - Forensic and Veterinary Standards
  6. Neat Compounds - Drugs & Metabolites
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Analytical Enzymes - Enzymes, Inhibitors, and Substrates
  5. Trypsin - Analytical Enzymes
  6. Trypsin Inhibitors
  1. Medical Research Areas
  2. Metabolism
  3. Factor Xa  (凝血因子 Xa)
  1. Medical Research Areas
  2. Metabolism
  3. Proteasome  (蛋白酶体)

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