3-氨基-1，4-二甲基-5h-吡啶[4,3-b]吲哚乙酸 3-氨基-1，4-二甲基-5h-吡啶[4,3-b]吲哚乙酸

CAS 68808-54-8 MFCD00210369

化学结构图

68808-54-8
SMILES: CC1=C(N)N=C(C)C2=C1NC1C=CC=CC=12.CC(O)=O

化学属性

Mol. FormulaC15H17N3O2
Mol. Weight271.31

别名和识别编码

Chemical Nametrp-p-1, acetate
CAS Number68808-54-8
Synonym 1,4-Dimethyl-5H-pyrido[4,3-b]indol-3-amine Monoacetate 3-Amino-1,4-dimethyl-5H-pyrido(4,3-b)indole acetate 5H-Pyrido(4,3-b)indol-3-amine, 1,4-dimethyl-, acetate 5H-Pyrido(4,3-b)indol-3-amine, 1,4-dimethyl-, monoacetate TRP-P-1 Acetate Trp-P-1 (acetate) trp-p-1, acetate
MDL NumberMFCD00210369
Chemical Name Translation3-氨基-1，4-二甲基-5h-吡啶[4,3-b]吲哚乙酸
PubChem Substance ID329792294
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分类

  • Mutagenesis Research Chemicals
  • Heterocycles
  • Amines
  • {SNA} Amines, Building Blocks, C15 to C19, Chemical Synthesis, Nitrogen Compounds, Organic Building Blocks

产品应用

  • Trp-P-1 is highly mutagenic in the Ames test. Investigations have shown that broiled fish, fried beef and commercial beef extracts, and protein pyrolysates contain this mutagen.

相关文献及参考

  • Eisenbrand, et al.: Toxicology, 84, 1 (1993),
  • Hosaka, S., et al.: Cancer Lett., 13, 23 (1981),
  • Ohgaki, H., et al.: Carcinogenesis, 5, 921 (1984),
  • Sugimura, T., et al.: Mutation Res., 290, 43 (1993),

安全信息

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 11 gm/kg/89W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Liver - tumors
REFERENCE :
   SCIEAS Science.  (American Assoc. for the Advancement of Science, 1333 H
   St., NW, Washington, DC 20005)  V.1-    1895-  Volume(issue)/page/year:
   213,346,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1539 mg/kg/29W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB
   211, 1000 AE Amsterdam, Netherlands)  V.76-    1985-
   Volume(issue)/page/year: 76,815,1985

RTECSUU9352000 
TYPE OF TEST            : DNA adduct
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 252 mg/kg/4W (Continuous)
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 256,37,1991

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 ug/plate
REFERENCE :
   CPBTAL Chemical and Pharmaceutical Bulletin.  (Japan Pub. Trading Co., USA,
   1255 Howard St., San Francisco, CA 94103)  V.6-    1958-
   Volume(issue)/page/year: 26,611,1978

{

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 150 mg/kg/48H (Intermittent)
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 389,3,1997

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 20 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 251,59,1991

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 25 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 395,57,1997

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 1 umol/L
REFERENCE :
   JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, P

WGK Germany3
GHS Symbol
Precautionary statements
  • P301+P310
Signal word Danger
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
Hazard Codes T
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒

系列性分类

  1. C14 to C16 - Amines

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