(2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-2-(((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-Dihydroxy-17-((S)-2-Hydroxy-6-Methylhept-5-En-2-Yl)-4,4,8,10,14-Pentamethylhexadecahydro-1H-Cyclopenta[A]Phenanthren-6-Yl)Oxy)-4,5-Dihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3-Yl)Oxy)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3,4,5-Triol (2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-2-(((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-二羟基-17-((S)-2-羟基-6-甲基庚-5-烯-2-基)-4,4,8,10,14-五甲基十六氢-1H-环戊[a]菲-6-基)氧基)-4,5-二羟基-6-(羟甲基)四氢-2H-吡喃-3-基)氧基)-6-(羟甲基)四氢-2H-吡喃-3,4,5-三醇

CAS 52286-58-5 MFCD00210509

化学结构图

52286-58-5
SMILES: CC1(C)[C@@H]2[C@H](C[C@]3(C)[C@H](C[C@@H](O)[C@@H]4[C@H](CC[C@@]34C)[C@@](C)(O)CCC=C(C)C)[C@@]2(C)CC[C@@H]1O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

化学属性

Mol. FormulaC42H72O14
Mol. Weight801
Density1.33

别名和识别编码

Chemical Name(2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-2-(((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-Dihydroxy-17-((S)-2-Hydroxy-6-Methylhept-5-En-2-Yl)-4,4,8,10,14-Pentamethylhexadecahydro-1H-Cyclopenta[A]Phenanthren-6-Yl)Oxy)-4,5-Dihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3-Yl)Oxy)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3,4,5-Triol
Synonym (3β,6α,12β)-3,12,20-Trihydroxydammar-24-en-6-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside (3β,6α,12β)-3,12,20-Trihydroxydammar-24-en-6-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside 人参皂甙Rf 人参皂苷 Rf
MDL NumberMFCD00210509
CAS Number52286-58-5
EC Number250-023-7
Beilstein Registry Number2384789
Chemical Name Translation(2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-2-(((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-二羟基-17-((S)-2-羟基-6-甲基庚-5-烯-2-基)-4,4,8,10,14-五甲基十六氢-1H-环戊[a]菲-6-基)氧基)-4,5-二羟基-6-(羟甲基)四氢-2H-吡喃-3-基)氧基)-6-(羟甲基)四氢-2H-吡喃-3,4,5-三醇
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分类

  • {SA} Alphabetic, Analytical Standards, Analytical/Chromatography, G, Nutrition Research, Panax ginseng, Phytochemicals by Plant (Food/Spice/Herb)
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, G, Nutrition Research, Panax ginseng, Phytochemicals by Plant (Food/Spice/Herb)
  • {SNA} Analytical Standards, Isoprenoids, Panax ginseng, Phytochemical Standards, Phytochemicals by Plant (Food/Spice/Herb), 分析/色谱, 细胞生物学, 营养研究

产品应用

  • A glycoside found to mediate lipoprotein metabolism

相关文献及参考

  • [2]. Mogil JS, et al. Ginsenoside Rf, a trace component of ginseng root, produces antinociception in mice. Brain Res. 1998 May 11;792(2):218-28.
  • [1]. Nah SY, et al. A trace component of ginseng that inhibits Ca 2+ channels through a pertussis toxin-sensitive G protein. Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8739-43.
  • [1]. Nah SY, et al. A trace component of ginseng that inhibits Ca 2+ channels through a pertussis toxin-sensitive G protein. Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8739-43.
  • [2]. Mogil JS, et al. Ginsenoside Rf, a trace component of ginseng root, produces antinociception in mice. Brain Res. 1998 May 11;792(2):218-28.

安全信息

GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
WGK Germany3
Signal word
RTECSLY9536900
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
Hazard Codes Xn
Storage condition 储存温度2-8℃ 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1340 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 25,539,1975

其他信息

  • Ginsenoside Rf, a glycoside of protopanaxatriol from Panax ginseng, is shown to be a biologically active saponin found to regulate lipoprotein metabolism. Mechanistic studies report that this regulation is done via altering of peroxisome proliferator-activated receptor α (PPARα)-mediated pathways. PPARα has demonstrated the ability to regulate C-III mRNA and basal levels of hepatic apoA-I (apolipoprotein A-I) which affect lipoprotein metabolism. Additional experiments have also observed this Ginsenoside Rf's ability to inhibit Ca2+ channels in mammalian sensory neurons in vitro.

系列性分类

  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Plant (Food/Spice/Herb) - Nutrition Research
  4. Panax ginseng - Phytochemicals by Plant (Food/Spice/Herb)
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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