(2S,3S,4R,6S)-6-(((2R,3S,4R,5R,6S)-6-(((4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-Acetoxy-10-Hydroxy-5-Methoxy-9,16-Dimethyl-2-Oxo-7-(2-Oxoethyl)Oxacyclohexadeca-11,13-Dien-6-Yl)Oxy)-4-(Dimethylamino)-5-Hydroxy-2-Methyltetrahydro-2H-Pyran-3-Yl)Oxy)-4-Hydroxy-2,4- 交沙霉素

CAS 16846-24-5 MFCD00211043

化学结构图

16846-24-5
SMILES: CC(=O)O[C@@H]1CC(=O)O[C@H](C)CC=CC=C[C@H](O)[C@H](C)C[C@H](CC=O)[C@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(OC(=O)CC(C)C)[C@@H](O)[C@H](C)O3)[C@@H]([C@H]2O)N(C)C)[C@H]1OC |t:12,14|

化学属性

Mol. FormulaC42H69NO15
Mol. Weight827.99
TSCANo

别名和识别编码

Chemical Name(2S,3S,4R,6S)-6-(((2R,3S,4R,5R,6S)-6-(((4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-Acetoxy-10-Hydroxy-5-Methoxy-9,16-Dimethyl-2-Oxo-7-(2-Oxoethyl)Oxacyclohexadeca-11,13-Dien-6-Yl)Oxy)-4-(Dimethylamino)-5-Hydroxy-2-Methyltetrahydro-2H-Pyran-3-Yl)Oxy)-4-Hydroxy-2,4-
CAS Number16846-24-5
Synonym Kitasamycin A3 Josamycin Jomybel Josacine Antibiotic yl-704 A3 Yl-704 A3 3-Acetate 4B-(3-methylbutanoate)leucomycin V Antibiotic YL 704A3 Wilprafen Vilprafen Josamina Leucomycin A3 Turimycin A5 Iosalide EN 141
MDL NumberMFCD00211043
EC Number240-871-6
PubChem Substance ID24881768
Merck Number14,5267
Chemical Name Translation交沙霉素
Wiswesser Line NotationT-16-OV KU MUTJ DOV1 EO1 G1VH I1 JQ P1 FO- BT6OTJ CQDN1&1 F1 EO- FT6OTJ B1 COV1Y1&1 DQ D1
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分类

  • {SNA} A - K, Antibacterial, Antibiotics A to Z, Antibiotics G-M, Chemical Structure Class, Interferes with Protein Synthesis, Macrolides, Mechanism of Action, Spectrum of Activity, 抗生素, 生化试剂
  • Chiral Reagents
  • Heterocycles
  • Pharmaceuticals
  • {SA} A - K, Alphabetic, Analytical Standards, Analytical/Chromatography, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics G-M, Chemical Structure, Chemical Structure Class, Chromatography, Clinical Standards, Interferes with Protein Synthesis, J,

产品应用

  • A 16-membered ring macrolide antibiotic with antimicrobial activity against a wide range of pathogens. Particularly used in the treatment of Mycoplasma infection.

相关文献及参考

  • Osono, T. et al.: J. Antibiot., 27, 366 (1974); Kuriaki, K. et al.: Jpn. J. Antibiot., 22, 232 (1969); Tan K. et al.: Zhonghua Yiyuamganranxue Zazhi, 16, 235 (2006);

安全信息

WGK Germany2
Personal Protective Equipment Eyeshields, Gloves Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECSOH4725810 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

{hazard_c

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 786 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HINAAU Hindustan Antibiotics Bulletin.  (Hindustan Antibiotics, Ltd.,
   Pimpri, Poona, India) V.1-    1958-  Volume(issue)/page/year: 11,26,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 520 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HINAAU Hindustan Antibiotics Bulletin.  (Hindustan Antibiotics, Ltd.,
   Pimpri, Poona, India) V.1-    1958-  Volume(issue)/page/year: 11,26,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >7 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,364,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 385 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HINAAU Hindustan Antibiotics Bulletin.  (Hindustan Antibiotics, Ltd.,
   Pimpri, Poona, India) V.1-    1958-  Volume(issue)/page/year: 11,26,1969

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 21 gm/kg
SEX/DURATION            : female 7-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   JJANAX Japanese Journal of Antibiotics.  (Japan Antibiotics Research Assoc.,
   2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan)  V.21-    1968-
   Volume(issue)/page/year: 22,219,1969

系列性分类

  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics G-M - Antibiotics A to Z
  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Spectrum of Activity - Antibiotics
  4. Antibacterial - Spectrum of Activity
  5. A - K - Antibacterial

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