(2S,2’S)-2,2’-(Ethane-1,2-Diylbis(Azanediyl))Bis(Butan-1-Ol) Dihydrochloride (S,S)-N,N’-双(1-羟基-2-丁基)乙二胺二盐酸盐

CAS 1070-11-7 MFCD00216025

化学结构图

1070-11-7
SMILES: CC[C@H](CO)NCCN[C@H](CC)CO.Cl.Cl

化学属性

Mol. FormulaC10 H24 N2 O2 . 2 Cl H
Mol. Weight277.23
Melting Point199.0 to 204.0 deg-C
TSCANo
SolubilityDMSO 56 mg/mL Water 56 mg/mL Ethanol <1 mg/mL

别名和识别编码

Chemical Name(2S,2’S)-2,2’-(Ethane-1,2-Diylbis(Azanediyl))Bis(Butan-1-Ol) Dihydrochloride
CAS Number1070-11-7
Synonym (+)-2,2'-(Ethylenediimino)di-1-butanol dihydrochloride (S,S)-2,2?-(1,2-Ethanediyldiimino)-bis-1-butanol Dihydrochloride 1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, dihydrochloride, 1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, dihydrochloride, (2S,2'S)- 1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, dihydrochloride, [S-(R*,R*)]- 1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, hydrochloride (1?), (2S,2'S)- 1-Butanol, 2,2'-(ethylenediimino)di-, dihydrochloride, (+)- (8CI) 2,2′-(1,2-Ethanediyldiimino)bis-1-butanol dihydrochloride Emb 2,2'-(1,2-ETHANEDIYLDIIMINO)BIS-1-BUTANOL DIHYDROCHLORIDE 2,2'-(1,2-Ethanediyldiimino)bis-1-butanol dihydrochloride 2,2'-(1,2-Ethanediyldiimino)bis-1-butanol dihydrochloride; [S-(R*,R*)]-2,2'-(Ethylenediimino)dibutan-1-ol dihydrochloride 2,2'-(1,2-乙二胺)二-1-丁醇二盐酸盐 2,2’-(1,2-ethanediyldiimino)bi
MDL NumberMFCD00216025
PubChem Substance ID14051
EC Number213-970-7
Merck Number3720
Chemical Name Translation(S,S)-N,N’-双(1-羟基-2-丁基)乙二胺二盐酸盐
Wiswesser Line NotationQ1Y2&M2MY2&1Q &GH 2
InChIInChI=1S/C10H24N2O2.2ClH/c1-3-9(7-13)11-5-6-12-10(4-2)8-14;;/h9-14H,3-8H2,1-2H3;2*1H/t9-,10-;;/m0../s1
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分类

  • Chiral Reagents
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,
  • {SNA} A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antimycobacterial, Interferes with Cell Wall Synthesis, Mechanism of Action, Spectrum of Activity

产品应用

  • A tuberculostatic antibacterial.

相关文献及参考

  • Wilkinson, et al.: J. Med. Chem., 5, 835 (1962),
  • Kulig, et al.: Diss. Pharm. Pharmacol., 23, 463 (1971),

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P308+P313
  • P201 Obtain special instructions before use. 使用前获取专门指示。
Hazard statements
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
RTECSEL3854000
Signal word Danger
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Codes T
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Risk Statements
  • R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
Storage condition +4°C 储存温度-20°C 储存温度2-8℃
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 45 mg/kg/3D-I
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - visual field changes
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
REFERENCE :
   BJDCAT British Journal of Diseases of the Chest.  (Bailliere Tindall, 33 The
   Avenue, Eastbourne BN21 3UN, UK)  V.53-    1959- Volume(issue)/page/year:
   80,288,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 2,70,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 6800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 2,70,1968

TY

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OB

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 230 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
REFERENCE :
   IRLCDZ IRCS Medical Science: Library Compendium.  (Lancaster, UK)  V.3-11,
   1975-83. For publisher information, see IMSCE2.  Volume(issue)/page/year:
   10,135,1982

TYPE OF TEST            : Sperm Morphology
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 12500 ug/kg
REFERENCE :
   IRLCDZ IRCS Medical Science: Library Compendium.  (Lancaster, UK)  V.3-11,
   1975-83. For publisher information, see IMSCE2.  Volume(issue)/page/year:
   10,135,1982

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 4400 mg/L
REFERENCE :
   IMSCE2 IRCS Medical Science.  (Lancaster, UK)  V.12-14, 1984-86.  For
   publisher information, see MSCREJ.  Volume(issue)/page/year: 14,745,1986

其他信息

  • Sigma Aldrich:1070-11-7(sigmaaldrich)
  • MOL 文件:1070-11-7.mol
  • Ethambutol dihydrochloride
  • Ethambutol HCl是一种抗分枝杆菌抑菌剂, 通过抑制阿拉伯糖基转移酶来干扰细胞壁形成。

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