2-Amino-9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)-8-Hydroxy-1H-Purin-6(9H)-One 2-氨基-9-((2R,3R,4S,5R)-3,4-二羟基-5-(羟甲基)四氢呋喃-2-基)-8-羟基-1H-嘌呤-6(9H)-酮
CAS 3868-31-3 MFCD00216136
化学结构图
SMILES: Nc1nc2c([nH]c(=O)n2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1
化学属性
| Mol. Formula | C10H13N5O6 |
|---|---|
| Mol. Weight | 299.2401 |
别名和识别编码
| Chemical Name | 2-Amino-9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)-8-Hydroxy-1H-Purin-6(9H)-One |
|---|---|
| CAS Number | 3868-31-3 |
| Synonym | 2-Amino-9-?-D-ribofuranosyl-purine-6,8(1H,9H)-dione |
| MDL Number | MFCD00216136 |
| Chemical Name Translation | 2-氨基-9-((2R,3R,4S,5R)-3,4-二羟基-5-(羟甲基)四氢呋喃-2-基)-8-羟基-1H-嘌呤-6(9H)-酮 |
| InChIKey | FPGSEBKFEJEOSA-UMMCILCDSA-N |
| PubChem Substance ID | 135407175 |
| InChI | InChI=1S/C10H13N5O6/c11-9-13-6-3(7(19)14-9)12-10(20)15(6)8-5(18)4(17)2(1-16)21-8/h2,4-5,8,16-18H,1H2,(H,12,20)(H3,11,13,14,19)/t2-,4-,5-,8-/m1/s1 |
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分类
- Carbohydrates & Derivatives
- Metabolites & Impurities
- Nucleotides
- Bases & Related Reagents
产品应用
- It is a representative metabolite derived by the oxidation of Guanosine (G) and is regarded as a marker of oxidative stress in the cells.
相关文献及参考
- [2]. Abe T, et al. Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer's disease. J Neurosci Res. 2002 Nov 1;70(3):447-50.
- Knaapen, A., et al.: Mutagenesis, 21, 225 (2006),
- Lin, T.-S. et al.: J. Med. Chem., 28, 1194 (1985),
- Risom, L., et al.: Mutat. Res., 592, 119 (2005),
- [1]. Fiala ES, et al. Oxidative DNA and RNA damage in the livers of Sprague-Dawley rats treated with the hepatocarcinogen 2-nitropropane. Cancer Res. 1989 Oct 15;49(20):5518-22.
- [1]. Fiala ES, et al. Oxidative DNA and RNA damage in the livers of Sprague-Dawley rats treated with the hepatocarcinogen 2-nitropropane. Cancer Res. 1989 Oct 15;49(20):5518-22.
- [2]. Abe T, et al. Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer's disease. J Neurosci Res. 2002 Nov 1;70(3):447-50.
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