Yangonin 甲氧醉椒素
CAS 500-62-9 MFCD00221733
化学结构图
SMILES: COc1ccc(/C=C/c2cc(OC)cc(=O)o2)cc1
化学属性
| Mol. Formula | C15H14O4 |
|---|---|
| Mol. Weight | 258 |
别名和识别编码
| Chemical Name | Yangonin |
|---|---|
| CAS Number | 500-62-9 |
| Synonym | 4-Methoxy-6-((E)-4-methoxystyryl)pyran-2-one 4-Methoxy-6-(p-methoxystyryl)-2H-pyran-2-one yangonin |
| Chemical Name Translation | 甲氧醉椒素 |
| Wiswesser Line Notation | T6OVJ DO1 F1U1R DO1 |
| Beilstein Registry Number | 230710 |
| LabNetwork Molecule ID | LN01314158 |
| PubChem Substance ID | 5281575 |
| InChI | InChI=1S/C15H14O4/c1-17-12-6-3-11(4-7-12)5-8-13-9-14(18-2)10-15(16)19-13/h3-10H,1-2H3/b8-5+ |
| MDL Number |
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分类
- Aromatics
- Heterocycles
- Mutagenesis Research Chemicals
产品应用
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相关文献及参考
- [2]. Ma J, et al. Yangonin blocks tumor necrosis factor-α-induced nuclear factor-κB-dependent transcription by inhibiting the transactivation potential of the RelA/p65 subunit. J Pharmacol Sci. 2012;118(4):447-54.
- [3]. Wruck CJ, et al. Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation. Mol Pharmacol. 2008 Jun;73(6):1785-95.
- Clouatre, D., et al.: Toxicol. Lett., 150, 85 (2004),
- Keledjian, J., et al.: J. Pharm. Sci., 77, 1003 (1988),
- [1]. Ligresti A, et al. Kavalactones and the endocannabinoid system: the plant-derived yangonin is a novel CB 1 receptor ligand. Pharmacol Res. 2012 Aug;66(2):163-9.
- [1]. Ligresti A, et al. Kavalactones and the endocannabinoid system: the plant-derived yangonin is a novel CB 1 receptor ligand. Pharmacol Res. 2012 Aug;66(2):163-9.
- [2]. Ma J, et al. Yangonin
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >1500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 177,261,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >1500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 177,261,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 41 mg/kg TOXIC EFFECTS : Behavioral - anticonvulsant REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 177,261,1969
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P301+P312
- P330 Rinse mouth. 漱口
- P501 Dispose of contents/container to..… 处理内容物/容器.....
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