6-Mercaptopurine 6-巯基嘌呤，无水

CAS 50-44-2 MFCD00233552

化学结构图

50-44-2
SMILES: S=c1[nH]cnc2[nH]cnc12

化学属性

Mol. FormulaC5H4N4S
Mol. Weight152.18
Appearance Solid powder
SolubilitySoluble in DMSO, not in water
Melting Point241-244 °C
Boiling Point471.018 °C at 760 mmHg

别名和识别编码

Chemical Name6-Mercaptopurine
Chemical Name Translation6-巯基嘌呤，无水
LabNetwork Molecule IDLN00222396
PubChem Substance ID667490
InChIInChI=1S/C5H4N4S/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
Synonym 6-Mercaptopurine {LY} 6-Mercaptopurine {} {LY} 6-Mercaptopurine {} {} {LY} 6-Mercaptopurine {} {} {} {LY} 6-Mercaptopurine {} {} {} {} {LY} 6-Mercaptopurine {} {} {} {} {} {LY} 6-Mercaptopurine {} {} {} {} {} {} {LY} 6-Mercaptopurine {} {} {} {} {} {} {} {LY} 6-Mercaptopurine {} {} {} {} {} {} {} {} {LY} 6-Mercaptopurine {} {} {} {} {} {} {} {} {} {LY} 6-Mercaptopurine {} {} {} {} {} {} {} {} {} {} {LY} 6-Mercaptopurine {} {} {} {} {} {} {} {} {} {} {} {LY} 6-Mercaptopurine {} {} {} {} {} {} {} {} {} {} {} {} {LY} 6-Mercaptopurine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 6-Mercaptopurine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 6-Mercaptopurine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 6-Mercaptopurine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 6-Mercaptopurine
FormulaC5H4N4S
IUPAC Name1H-purine-6(7H)-thione.
InChIKeyGLVAUDGFNGKCSF-UHFFFAOYSA-N
CAS Number50-44-2
Canonical SMILESS=C1NC=NC2=C1NC=N2
MDL NumberMFCD00233552
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产品应用

  • Mercaptopurine is a thiopurine-derivative antimetabolite with antineoplastic and immunosuppressive activities. Produced through the metabolism of mercaptopurine by hypoxanthine-guanine phosphoribosyltransferase (HGPRT), mercaptopurine metabolites 6-thioguanosine-5'-phosphate (6-thioGMP) and 6-thioinosine (T-IMP) inhibit nucleotide interconversions and de novo purine synthesis, thereby blocking the formation of purine nucleotides and inhibiting DNA synthesis.

相关文献及参考

  • [2]. Liu Q, et al. 6-Mercaptopurine augments glucose transport activity in skeletal muscle cells in part via a mechanism dependent upon orphan nuclear receptor NR4A3. Am J Physiol Endocrinol Metab. 2013 Nov 1;305(9):E1081-92.
  • [3]. Kanemitsu H, et al. 6-Mercaptopurine (6-MP) induces cell cycle arrest and apoptosis of neural progenitor cells in the developing fetal rat brain. Neurotoxicol Teratol. 2009 Mar-Apr;31(2):104-9.
  • [1]. Sahasranaman S, et al. Clinical pharmacology and pharmacogenetics of thiopurines. Eur J Clin Pharmacol. 2008 Aug;64(8):753-67.
  • [1]. Sahasranaman S, et al. Clinical pharmacology and pharmacogenetics of thiopurines. Eur J Clin Pharmacol. 2008 Aug;64(8):753-67.
  • [2]. Liu Q, et al. 6-Mercaptopurine augments glucose transport activity in skeletal muscle cells in part via a mechanism dependent upon orphan nuclear receptor NR4A3. Am J Physiol Endocrinol Metab. 2013 Nov 1;305(9):E1081-92.
  • [3]. Kanemitsu H, et al. 6-Mercapt

安全信息

Hazard statements
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P310
  • P301+P312
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P307+P311
  • P308+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect fr

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Dehydrogenase
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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