N-(trans-4-Hydroxycyclohexyl)-2-amino-3,5-dibromobenzylamine 2-氨基-3,5-二溴-N-(反式4-羟基环己基)苄胺

CAS 18683-91-5 MFCD00242702

化学结构图

18683-91-5
SMILES: NC1C(CN[C@@H]2CC[C@@H](O)CC2)=CC(Br)=CC=1Br |&1:5,8|

化学属性

Mol. FormulaC13H19Br2ClN2O
Mol. Weight415

别名和识别编码

Chemical NameN-(trans-4-Hydroxycyclohexyl)-2-amino-3,5-dibromobenzylamine
EC Number242-500-3
Synonym 2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine; Ambroxol base trans-4-((2-Amino-3,5-dibromobencil)amino)ciclohexanol N-(2-Amino-3,4-dibromocyclohexyl)-trans-4-aminocyclohexanol N-(trans-4-Hidroxiciclohexil)-(2-amino-3,5-dibromobencil)amina Ambroxol N-(trans-4-Hydroxycyclohexyl)-(2-amino-3,5-dibromobenzyl)-amine Cyclohexanol, 4-(((2-amino-3,5-dibromophenyl)methyl)amino)-, trans- N-(trans-p-Hydroxycyclohexyl)-(2-amino-3,5-dibromobenzyl)amine N-(2-Amino-3,4-dibromociclohexil)-trans-4-aminociclohexanol NA-872 trans-4-((2-Amino-3,5-dibromobenzyl)amine)cyclohexanol
CAS Number18683-91-5
Wiswesser Line NotationL6TJ AQ DM1R BZ CE EE
Chemical Name Translation2-氨基-3,5-二溴-N-(反式4-羟基环己基)苄胺
MDL Number
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相关文献及参考

  • [2]. Anna Migdalska-Richards, et al. Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice. Ann Neurol. 2016 Nov;80(5):766-775.
  • [1]. Vojo Deretic, et al. Enhancement of lung levels of antibiotics by ambroxol and bromhexine. Expert Opin Drug Metab Toxicol. 2019 Mar;15(3):213-218.
  • [1]. Vojo Deretic, et al. Enhancement of lung levels of antibiotics by ambroxol and bromhexine. Expert Opin Drug Metab Toxicol. 2019 Mar;15(3):213-218.
  • [2]. Anna Migdalska-Richards, et al. Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice. Ann Neurol. 2016 Nov;80(5):766-775.

安全信息

Hazard Codes Xn
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
RTECSGV8423000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - m

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 380 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MDACAP Medicamentos de Actualidad.  (J.R. Prous, S.A., Apartado de Correos
   540, 08080 Barcelona, Spain)  V.1-    1965-  Volume(issue)/page/year:
   15,523,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 280 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MDACAP Medicamentos de Actualidad.  (J.R. Prous, S.A., Apartado de Correos
   540, 08080 Barcelona, Spain)  V.1-    1965-  Volume(issue)/page/year:
   15,523,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 1180 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MDACAP Medicamentos de Actualidad.  (J.R. Prous, S.A., Apartado de Correos
   540, 08080 Barcelona, Spain)  V.1-    1965-  Volume(issue)/page/year:
   15,523,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 13400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MDACAP Medicamentos de Actualidad.  (J.R. Prous, S.A., Apartado de Correos
   540, 08080 Barcelona, Spain)  V.1-    1965-  Volume(issue)/page/year:

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. A - Alphabetic
  5. AM to AQ - A
  1. Medical Research Areas
  2. Metabolism
  3. Glucosidase  (葡萄糖苷酶)

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