Ambroxol 氨溴索碱
CAS 18683-91-5 MFCD00242702
化学结构图
SMILES: NC1C(CN[C@@H]2CC[C@@H](O)CC2)=CC(Br)=CC=1Br |&1:5,8|
化学属性
| Mol. Formula | C13H19Br2ClN2O |
|---|---|
| Mol. Weight | 415 |
别名和识别编码
| Chemical Name | Ambroxol |
|---|---|
| EC Number | 242-500-3 |
| Synonym | 2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine; Ambroxol base trans-4-((2-Amino-3,5-dibromobencil)amino)ciclohexanol N-(2-Amino-3,4-dibromocyclohexyl)-trans-4-aminocyclohexanol N-(trans-4-Hidroxiciclohexil)-(2-amino-3,5-dibromobencil)amina Ambroxol N-(trans-4-Hydroxycyclohexyl)-(2-amino-3,5-dibromobenzyl)-amine Cyclohexanol, 4-(((2-amino-3,5-dibromophenyl)methyl)amino)-, trans- N-(trans-p-Hydroxycyclohexyl)-(2-amino-3,5-dibromobenzyl)amine N-(2-Amino-3,4-dibromociclohexil)-trans-4-aminociclohexanol NA-872 trans-4-((2-Amino-3,5-dibromobenzyl)amine)cyclohexanol |
| CAS Number | 18683-91-5 |
| Wiswesser Line Notation | L6TJ AQ DM1R BZ CE EE |
| Chemical Name Translation | 氨溴索碱 |
| MDL Number |
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相关文献及参考
- [2]. Anna Migdalska-Richards, et al. Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice. Ann Neurol. 2016 Nov;80(5):766-775.
- [1]. Vojo Deretic, et al. Enhancement of lung levels of antibiotics by ambroxol and bromhexine. Expert Opin Drug Metab Toxicol. 2019 Mar;15(3):213-218.
- [1]. Vojo Deretic, et al. Enhancement of lung levels of antibiotics by ambroxol and bromhexine. Expert Opin Drug Metab Toxicol. 2019 Mar;15(3):213-218.
- [2]. Anna Migdalska-Richards, et al. Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice. Ann Neurol. 2016 Nov;80(5):766-775.
安全信息
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R22 Harmful if swallowed 吞咽有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - m
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 380 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 15,523,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 280 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 15,523,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 1180 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 15,523,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 13400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year:
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