4-(4-Chlorobenzyl)-2-(1-Methylazepan-4-Yl)Phthalazin-1(2H)-One 4-(4-氯苄基)-2-(1-甲基氮杂环庚烷-4-基)酞嗪-1(2H)-酮
CAS 58581-89-8 MFCD00242781
化学结构图
SMILES: CN1CCCC(CC1)N1N=C(CC2C=CC(Cl)=CC=2)C2C=CC=CC=2C1=O
化学属性
| Mol. Formula | C22H24ClN3O·HCl |
|---|---|
| Mol. Weight | 418.36 |
| Melting Point | 224.0 to 228.0 deg-C |
别名和识别编码
| Chemical Name | 4-(4-Chlorobenzyl)-2-(1-Methylazepan-4-Yl)Phthalazin-1(2H)-One |
|---|---|
| MDL Number | MFCD00242783 |
| Chemical Name Translation | 4-(4-氯苄基)-2-(1-甲基氮杂环庚烷-4-基)酞嗪-1(2H)-酮 |
| Wiswesser Line Notation | T66 BVNNJ E1R DG& C- DT7NTJ A1 |
| Synonym | Azelastine 4-(p-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1-(2H)-phthalazinone |
| Beilstein Registry Number | 0900747 |
| CAS Number | 58581-89-8 |
| Reaxys-RN | 4834474 |
| Merck Number | 906 |
| PubChem Substance ID | 125307599 |
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相关文献及参考
- [2]. Mohamed M Elseweidy, et al. Azelastine a potent antihistamine agent, as hypolipidemic and modulator for aortic calcification in diabetic hyperlipidemic rats model. Arch Physiol Biochem. 2020 Jul 2;1-8.
- [3]. Carlos D. Zappia, et al. Azelastine potentiates antiasthmatic dexamethasone effect on a murine asthma model. Pharmacol Res Perspect. 2019 Dec; 7(6): e00531.
- [4]. Li Yang, et al. Identification of SARS-CoV-2 entry inhibitors among already approved drugs. Acta Pharmacol Sin. 2020 Oct 28 : 1-7.
- [5]. Shao-Cheng Liu, et al. Effect of budesonide and azelastine on histamine signaling regulation in human nasal epithelial cells. Eur Arch Otorhinolaryngol. 2017 Feb;274(2):845-853.
- [1]. Craig La Force. Review of the pharmacology, clinical efficacy, and safety of azelastine hydrochl
- [1]. Craig La Force. Review of the pharmacology, clinical efficacy, and safety of azelastine hydrochloridel. Expert Rev Clin Immunol. 2005 Jul;1(2):191-201.
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 51300 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Gastrointestinal - nausea or vomiting REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,1184,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 43200 ug/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,1184,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 54200 ug/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,1184,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION
{h- H302 Harmful if swallowed 吞食有害
GHS Symbol
- P301+P312+P330
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
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