4-Hydroxytamoxifen 4-羟基三苯氧胺
CAS 68047-06-3 MFCD00278780
化学结构图
SMILES: CC/C(=C(\C1C=CC(O)=CC=1)/C1C=CC(=CC=1)OCCN(C)C)/C1C=CC=CC=1
化学属性
| Mol. Formula | C26H29NO2 |
|---|---|
| Mol. Weight | 387.51 |
别名和识别编码
| Chemical Name | 4-Hydroxytamoxifen |
|---|---|
| Synonym | (Z)-4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol (Z)-4-OHT (Z)-4-OHT (Z)-4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol trans-4-Hydroxytamoxifen trans-4-Hydroxytamoxifen |
| CAS Number | 68047-06-3 |
| PubChem Substance ID | 24895814 |
| MDL Number | MFCD00278780 |
| LabNetwork Molecule ID | LN00200350 |
| Chemical Name Translation | 4-羟基三苯氧胺 |
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信息真实价格透明
资金保障
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分类
- {SNA} Antibiotics, Antibiotics A to Z, Antibiotics G-M, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Approved Therapeutics/Drug Candidates, AstraZeneca, Bioactive Small Molecules, Cell Bio
- Antibiotics, Antibiotics A to Z, Antibiotics G-M, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Approved Therapeutics/Drug Candidates, AstraZeneca, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, H, Hormones, Other Steroid Products, Steroid Hormones
- {SNA} Antibiotics A to Z,
- {SNA} A
相关文献及参考
- Murphy CS, et al., Structure-function relationships of hydroxylated metabolites of tamoxifen that control the proliferation of estrogen-responsive T47D breast cancer cells in vitro Mol. Pharmacol. 38 , 737-743, (1990) 摘要
- Zhang CC, and Shapiro DJ., Activation of the p38 mitogen-activated protein kinase pathway by estrogen or by 4-hydroxytamoxifen is coupled to estrogen receptor-induced apoptosis J. Biol. Chem. 275 , 479-486, (2000) 摘要
- Obrero M, et al., Estrogen receptor-dependent and estrogen receptor-independent pathways for tamoxifen and 4-hydroxytamoxifen-induced programmed cell death J. Biol. Chem. 277 , 45695-45703, (2002) 摘要
- Rabenoelina F, et al., Effect of prolonged hydroxytamoxifen treatment of MCF-7 cells on mitogen activated kinase cascade Int. J. Cancer 98 , 698-706, (2002) 摘要
- Zhou JH, et al., Delayed and persistent ERK1/2 activation is required for 4-hydroxytamoxifen-induced cell death Steroids 72 , 765-777, (2007) 摘要
- Aesoy R, et al., An autocrine VEGF/VEGFR2 and p38 signaling loop confers resistance to 4-hydroxytamoxifen in MCF-7 breast cancer cells Mol. Cancer Res. 6 , 1630-1638, (2008) 摘要
- Kandilci, A., and Grosveld, G.C., Reintroduction of CEBPA in MN1-overexpressing hematopoietic cells prevents their hyperproliferation and restores myeloid differentiation Blood 114 , 1596-606, (2009) 摘要
- Cowley, D.O., et al., Aurora-A Kinase Is Essential For Bipolar Spindle Formation And Early Development. Mol. Cell. Biol. 29 , 1059-71, (2009) 摘要
- Minamishima, Y.A., et al., A Feedback Loop Involving The Phd3 Prolyl Hydroxylase Tunes The Mammalian Hypoxic Response In Vivo. Mol. Cell. Biol. 29 , 5729-41, (2009) 摘要
- Hans, S., et al., Temporally-controlled Site-specific Recombination In Zebrafish. PLoS ONE 4 , e4640, (2009) 摘
安全信息
GHS Symbol
- H332 Harmful if inhaled 吸入有害
- H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
- H302 Harmful if swallowed 吞食有害
- H312 Harmful in contact with skin 皮肤接触有害
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- S22 Do not breathe dust 不要吸入粉尘；
- S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
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