2’-(4-Aminophenyl)-1H,3’H-[2,5’-Bibenzo[D]Imidazol]-5-Amine 2’-(4-氨基苯基)-1H,3’H-[2,5’-联苯并[d]咪唑]-5-胺

CAS 293762-45-5 MFCD00367977

化学结构图

293762-45-5
SMILES: NC1C=CC(=CC=1)C1NC2C=C(C=CC=2N=1)C1NC2C=C(N)C=CC=2N=1

化学属性

Mol. FormulaC20H16N6
Mol. Weight340.38

别名和识别编码

Chemical Name2’-(4-Aminophenyl)-1H,3’H-[2,5’-Bibenzo[D]Imidazol]-5-Amine
Synonym 2'-(4-Aminophenyl)-[2,5'-bi-1H-benzimidazol]-5-amine Ro 90-7501
MDL NumberMFCD00367977
PubChem Substance ID24724587
Chemical Name Translation2’-(4-氨基苯基)-1H,3’H-[2,5’-联苯并[d]咪唑]-5-胺
CAS Number293762-45-5
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分类

  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, R, Roche
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, R, Roche, 生物活性小分子, 细胞生物学

相关文献及参考

  • [2]. Guo F, et al. RO 90-7501 enhances TLR3 and RLR agonist induced antiviral response. PLoS One. 2012;7(10):e42583.
  • [3]. Hong TJ, et al. Ro 90-7501 inhibits PP5 through a novel, TPR-dependent mechanism. Biochem Biophys Res Commun. 2017 Jan 8;482(2):215-220.
  • [4]. Bohrmann B, et al. Self-assembly of beta-amyloid 42 is retarded by small molecular ligands at the stage of structural intermediates. J Struct Biol. 2000 Jun;130(2-3):232-46.
  • [1]. Tamari K, et al. Ro 90-7501 Is a Novel Radiosensitizer for Cervical Cancer Cells that Inhibits ATM Phosphorylation. Anticancer Res. 2019 Sep;39(9):4805-4810.
  • [1]. Tamari K, et al. Ro 90-7501 Is a Novel Radiosensitizer for Cervical Cancer Cells that Inhibits ATM Phosphorylation. Anticancer Res. 2019 Sep;39(9):4805-4810.
  • [2]. Guo F, et al. RO 90-7501 enhances TLR3 and RLR agonist induced antiviral response. PLoS One. 2012;7(10):e42583.
  • [3]. Hong TJ, et al. Ro 90-7501 inhibits PP5 through a nov

安全信息

GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
WGK Germany3
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Hazard Codes Xi
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. R - Bioactive Small Molecules
  1. Medical Research Areas
  2. Metabolism
  3. Phosphatase  (磷酸酶)

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