2-Mercaptobenzimidazole 2-巯基苯并咪唑

CAS 583-39-1 MFCD00466107

化学结构图

583-39-1
SMILES: Sc1nc2ccccc2[nH]1

化学属性

Mol. FormulaC7H6N2S
Mol. Weight150
Density1.42
Flash Point>250°(487°F)
SolubilitySoluble in alcohol
TSCAYes
Melting Point300-305
Appearance 纯品为白色粉末。无臭但有苦味。 溶于丙酮、乙醇,不易溶于苯、汽油及水。

别名和识别编码

Chemical Name2-Mercaptobenzimidazole
Synonym 1,3-Dihydro-2H-benzimidazol-2-thion 1,3-Dihydro-be 1,3-dihydro-benzoimidazole-2-thione 1H-BENZIMIDAZOLE-2-THIOL 1H-Benzimidazole-2-thiol 2,3-Dihydro-1H-benzimidazole-2-thiol 2-Benzimidazolethiol 2-Benzimidazolthiol 2-MERCAPTOBENZIMIDAZOLE 2-Mercaptobenzimidazole 2-Thiobenzimidazole 2-benzimidazolinthion 2-mercaptoimidazole 2-mercatpo-1H-benzimidazole 2-巯基苯并咪唑 2-巯基苯并咪唑,98% AOMB Antiegene MB Antioxidant MB Benzimidazole-2-thiol Mercaptobenzoimidazole Nonflex Sumilizer MB Usaf ek-6540 Usaf xf-21 Vulkanox MBI bemityl {} {Chemicalb {} {} {Chemical {} {} {} {Chemicalbook} {} {} {} {} {} {} {Chem {} {} {} {}
MDL NumberMFCD00466107
CAS Number583-39-1
EC Number209-502-6
Merck Number1082
Beilstein Registry Number119867
PubChem Substance ID707035
Chemical Name Translation2-巯基苯并咪唑
Reaxys-RN606940
Wiswesser Line NotationT56 BM DNJ CSH
InChIInChI=1S/C7H6N2S/c10-7-8-5-3-1-2-4-6(5)9-7/h1-4H,(H2,8,9,10)
LabNetwork Molecule IDLN05016815
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分类

  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chromatography, Drugs & Metabolites, Forensic and Veterinary Standards, M, MEA - MES, Neat Compounds
  • {SNA} Benzimidazoles, Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks
  • {Chemicalbook}

产品应用

  • 用作检定金、铋、镉、钴、汞、镍、铅、铊和锌的灵敏试剂及橡胶促进剂。
  • 2-巯基苯并咪唑, 2-硫醇基苯并咪唑, 橡胶防老剂MB

相关文献及参考

  • Merck:14,1082
  • Merck:14,1082 Beilstein:24,119
  • Short: EINECS
  • Short: III/20a

安全信息

RTECSDE1050000
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
Packing GroupIII
UN Number 2811 UN 2811 6.1/PG 3
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
WGK Germany2
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P310+P330
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H332 Harmful if inhaled 吸入有害
  • H315 Causes skin irritation 会刺激皮肤
  • H301 Toxic if swallowed 吞食有毒
  • H312 Harmful in contact with skin 皮肤接触有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H312+H332
Signal word Danger
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes 6.1 Xn
Hazard Class6.1
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FRZKAP Farmatsevtichnii Zhurnal (Kiev).  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR) V.3-    1930-  Volume(issue)/page/year: 17(1),36,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD277-689

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 180 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#04376

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 660 mg/kg
SEX/DURATION            : female 7-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   25,218,1995

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 330 mg/kg
SEX/DURATION            : female 7-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   25,218,1995

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 110 mg/kg
SEX/DURATION            : female 7-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   25,218,1995

其他信息

  • 刺激数据:皮肤-兔子 500 毫克/24小时 轻度; 眼睛-兔子 500 毫克/24小时 轻度
  • 图谱信息:2-巯基苯并咪唑(583-39-1)质谱(MS) 2-巯基苯并咪唑(583-39-1)核磁图( 13 CNMR) 2-巯基苯并咪唑(583-39-1)核磁图( 1 HNMR) 2-巯基苯并咪唑(583-39-1)红外图谱(IR2) 2-巯基苯并咪唑(583-39-1)红外图谱(IR1)
  • 毒性分级:中毒
  • 用途三:主要用于合成橡胶、顺丁橡胶、丁苯橡胶、丁腈
  • TCI Shanghai:2-巯基苯并咪唑 2-Mercaptobenzimidazole,>;98.0%(T)(58
  • 方法一:将64 kg邻苯二胺、18 kg氢氧化钾,52 kg二硫化碳依次加入反应釜中。开动搅拌,再加入480 kg酒精,190 kg蒸馏水缓缓加热,使其溶解后,继续加热回流3 h。降温,停止沸腾后加入24 kg活性炭回流20 min,脱色。然后过滤除去活性炭。滤液放入结晶槽,加热至60~70 ℃,加热水300份。在搅拌下加入醋酸水溶液(30%~32%),使结晶完全。离心过滤,收集结晶于40 ℃下干燥,得成品。
  • 上游原料
  • {Chemi
  • 用途六:该品用作天然橡胶、二烯类合成橡胶及胶乳的抗氧剂,亦可用于聚乙烯。它是一种所谓的二次防老剂,与其他防老剂(如DNP、AP及其他非污染性防老剂)并用,可获得明显的协同效果。该品在橡胶中易分散,在日光下不变色。略有污染性。单独使用时用量和般为1-1.5份,当用量超过2份时,会产生喷霜现象。在乳胶泡沫橡胶中的用量为0.5-1份,在透明橡胶制品中的用量为0.5份。因本品有苦味,不宜用于与食品接触的橡胶制品中。2-巯基苯并咪唑在医药上是一种新抗麻疯药,毒性比砜类药物低,而疗效也底,可产生耐药性,无蓄积作用。可用于不适用砜类药物的患者。2-巯基并咪唑碱金属盐水溶液与水溶性锌盐溶液反应可得2-巯基苯并咪唑锌盐,即防老剂MBZ(C14H10N4S2Zn)。该品无毒。
  • 灭火剂:干粉,泡沫,沙土,二氧化碳, 雾状水
  • 急性毒性:口服-小鼠 LD50: 750 毫克/公斤; 腹腔-小鼠 LD50: 200 毫克/公斤
  • 用途二:用途:防老剂MB在橡胶工业上是主要的非污染性防老剂,能减少橡胶硫化时的变色。本品适于制造透明、白色及艳色制品,耐热及泡沫制品,本品不变色,不被污染。
  • Sigma Aldrich:583-39-1(sigmaaldrich)
  • Acros Organics:2-巯基苯并咪唑 2-Mercaptobenz
  • {Chemicalb
  • 2-巯基苯并咪唑价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw010352 2-巯基苯并咪唑;苯并二氮唑-2-硫酚 100g 80元 2011/08/23 LA1835001 2-巯基苯并咪唑;苯并二氮唑-2-硫酚 100g 214元 2011/08/23 30112714 2-巯基苯并噻唑;苯并噻唑硫醇;促进剂M;M快熟粉;2-巯基-1,3-硫氮茚 25g 29.3元
  • 下游产品:兰索拉唑
  • 用途四:对防止橡胶空气老化有效,特别适用于制造透明、白色和艳色制品
  • 用途六:该品用作天然橡胶、二烯类合成橡胶及胶乳的抗氧剂,亦可用于聚乙烯。它是一种所谓的二次防老剂,与其他防老剂(如DNP、AP及其他非污染性防老剂)并用,可获得明显的协同效果。该品在橡胶中易分散,在日光下不变色。略有污染性。单独使用时用量和般为1-1.5份,当用量超过2份时,会产生喷霜现象。在乳胶泡沫橡胶中的用量为0.5-1份,在透明橡胶制品中的用量为0.5份。因本品有苦味,不宜用于与食品接触的橡胶制品中。2-巯基苯并咪唑在医药上是一种新抗麻疯药,毒性比砜类药物低,而疗效也底,可产生耐药性,无蓄积作用。可用于不适用砜类药物的患者。2-巯基并咪唑碱金属盐水溶液与水溶性锌盐溶液反应可得2-巯基苯并咪唑锌盐,即防老剂MBZ(C14H10N4S2
  • 类别:有毒物品
  • 用途三:主要用于合成橡胶、顺丁橡胶、丁苯橡胶、丁腈橡胶及乳胶等

系列性分类


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