1-Methyl-L-tryptophan 1-甲基-L-色氨酸

CAS 21339-55-9 MFCD00467133

化学结构图

21339-55-9
SMILES: Cn1cc(C[C@H](N)C(=O)O)c2ccccc21

化学属性

Mol. FormulaC12H14N2O2
Mol. Weight218.25
Melting Point242-245 °C(lit.)
Density1.28
Danger-Level-
pH-:-
Redox-

别名和识别编码

Chemical NameH-Trp(1-Me)-OH
MDL NumberMFCD00467133
PubChem Substance ID24868339
Synonym 1-Methyltryptophan; L-(-)-1-Methyltryptophan; L-1-Methyltryptophan 1-甲基-L-色氨酸 1-Methyltryptophan
CAS Number21339-55-9
Chemical Name Translation1-甲基-L-色氨酸
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分类

  • {SNA} Amino Acid Derivatives, Chemical Biology, Chemical Synthesis, Peptide Chemistry, Tryptophan
  • {SNA} Amino Acids & Derivatives, Chemical Biology, Chemical Synthesis, Peptide Chemistry, Tryptophan

相关文献及参考

  • [2]. Liu X, et, al. 1-L-MT, an IDO inhibitor, prevented colitis-associated cancer by inducing CDC20 inhibition-mediated mitotic death of colon cancer cells. Int J Cancer. 2018 Sep 15;143(6):1516-1529.
  • [1]. Huang GL, et, al. PEG-Poly(1-Methyl-l-Tryptophan)-Based Polymeric Micelles as Enzymatically Activated Inhibitors of Indoleamine 2,3-Dioxygenase. Nanomaterials (Basel). 2019 May 9;9(5):719.
  • [1]. Huang GL, et, al. PEG-Poly(1-Methyl-l-Tryptophan)-Based Polymeric Micelles as Enzymatically Activated Inhibitors of Indoleamine 2,3-Dioxygenase. Nanomaterials (Basel). 2019 May 9;9(5):719.
  • [2]. Liu X, et, al. 1-L-MT, an IDO inhibitor, prevented colitis-associated cancer by inducing CDC20 inhibition-mediated mitotic death of colon cancer cells. Int J Cancer. 2018 Sep 15;143(6):1516-1529.

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECSYN7135000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 286 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 1,515,1976

Restrict -

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Amino Acids 氨基酸
  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Peptide Chemistry 多肽化学
  4. Amino Acid Derivatives 氨基酸及其衍生物
  5. Tryptophan - Amino Acid Derivatives
  1. Medical Research Areas
  2. Metabolism
  3. Indoleamine 2,3-Dioxygenase (IDO)  (吲哚胺 2,3 双加氧酶)

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