Phenol,3-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenyl-1-butenyl)-, (E)-

CAS 82413-20-5 MFCD82413205

化学结构图

82413-20-5
SMILES: CC/C(=C(\C1C=C(O)C=CC=1)/C1C=CC(=CC=1)OCCN(C)C)/C1C=CC=CC=1

化学属性

Mol. Weight387.56
Mol. FormulaC26H29NO2

别名和识别编码

CAS Number82413-20-5
Chemical NamePhenol,3-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenyl-1-butenyl)-, (E)-
Synonym K 060E (E)-3-(1-(4-(2-(Dimethylamino)ethoxy)phenyl)-2-phenyl-1-butenyl)phenol Droloxifene (E)-alpha-(para-(2-(Dimethylamino)ethoxy)phenyl)-alpha'-ethyl-3-stilbenol K 060 3-[(1E)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol 3-Hydroxytamoxifen trans-1-(4-beta-Dimethylaminoethoxyphenyl)-1-(3-hydroxyphenyl)-2-phenylbut-1-ene (E)-1-(4'-(2-Dimethylaminoethoxy)phenyl)-1-(3'-hydroxyphenyl)-2-phenylbut-1-ene E-Droloxifene K 21060E
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分类

  • Aromatics
  • Drug Analogues
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • A Tamoxifen (T006000) derivative with antitumor effect on estrogen-dependent breast cancer cells.

相关文献及参考

  • Ruenitz, P.C., et al.: J. Med. Chem., 25, 1056 (1982),
  • Shiina, I., et al.: Bioorg. Med. Chem., 15, 7599 (2007),
  • Jones, D., et al.: Drug Metab. Disposition, 35, 1466 (2007),

安全信息

RTECSSL1209900 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   9,186,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   9,186,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   9,186,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >4500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   9,186,1984

系列性分类

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