MG 132 MG132,蛋白酶体抑制剂

CAS 133407-82-6 MFCD00674886

化学结构图

133407-82-6
SMILES: CC(C)C[C@@H](NC(=O)OCC1C=CC=CC=1)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CC(C)C)C=O |&1:4,19,27|

化学属性

Mol. FormulaC26H41N3O5
Mol. Weight476
TSCANo
Density1.073
Boiling Point682

别名和识别编码

Chemical NameMG 132
Synonym MG-132 Z-Leu-Leu-Leu-al Z-Leu-Leu-Leu-aldehyde
MDL NumberMFCD00674886
PubChem Substance ID24892475
CAS Number133407-82-6
Chemical Name TranslationMG132,蛋白酶体抑制剂
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分类

  • {SNA} Aldehydes, Application Index, Building Blocks, C13-C60, Calpain and Proteasome Inhibitors, Carbonyl Compounds, Cell Signaling Enzymes, Chemical Synthesis, Inhibitors, Organic Building Blocks, Proteasome, Calpain and Lysosomal Proteases, Proteasomes,

相关文献及参考

  • [2]. Fan WH, et al. Proteasome inhibitor MG-132 induces C6 glioma cell apoptosis via oxidative stress. Acta Pharmacol Sin. 2011 May;32(5):619-25.
  • [3]. Tsubuki S, et al. Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine. J Biochem. 1996 Mar;119(3):572-6.
  • [4]. Fiedler MA, et al. Inhibition of TNF-alpha-induced NF-kappaB activation and IL-8 release in A549 cells with the proteasome inhibitor MG-132. Am J Respir Cell Mol Biol. 1998 Aug;19(2):259-68.
  • [5]. MacLaren AP, et al. p53-dependent apoptosis induced by proteasome inhibition in mammary epithelial cells. Cell Death Differ. 2001 Mar;8(3):210-8.
  • [6]. Han YH, et al. The effect of MG132, a proteasome inhibitor on HeLa cells in relation to cell growth, reactive oxygen species and GSH. Oncol Rep. 2009 Jul;22(1):215-21.
  • [7]. Dang L, et al. Proteasome inhibitor MG132 inhibits the proliferation and promotes the cisplatin-indu

安全信息

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK Germany3
GHS Symbol
Signal word Warning
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Aldehydes - Carbonyl Compounds
  6. C13-C60 - Aldehydes
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Application Index - Enzymes, Inhibitors, and Substrates
  5. Cell Signaling Enzymes - Application Index
  6. Proteasome, Calpain and Lysosomal Proteases - Cell Signaling Enzymes
  7. Proteasomes - Proteasome, Calpain and Lysosomal Proteases
  8. Inhibitors - Proteasomes
  1. Medical Research Areas
  2. Metabolism
  3. Proteasome  (蛋白酶体)

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