4,6-Dichloro-2-phenylpyrimidine 4,6-二氯-2-苯基-嘧啶

CAS 3740-92-9 MFCD00754193

化学结构图

3740-92-9
SMILES: Clc1cc(Cl)nc(-c2ccccc2)n1

化学属性

Mol. FormulaC10H6Cl2N2
Mol. Weight225.07
Melting Point92-93°C
Appearance 无色结晶。熔点96.9℃,相对密度1.5,溶于丙酮、环己酮、二氯甲烷、甲苯、二甲苯,微溶于己烷、甲醇、正辛醇、异丙醇。
Density1.363
Boiling Point235.5°C at 760 mmHg

别名和识别编码

Chemical NameFenclorim, 98%
CAS Number3740-92-9
Alfabeta NameDICHLOROPHENYLPYRIMIDINE 462---,
MDL NumberMFCD00754193
Synonym 4,6-Dichloro-2-phenylpyrimidine {LY} 4,6-Dichloro-2-phenylpyrimidine 4,6-dichloro-2-phenylpyrimidine fenclorim {} {LY} 4,6-Dichloro-2-phenylpyrimidine {} {} {LY} 4,6-Dichloro-2-phenylpyrimidine {} {} {} {LY} 4,6-Dichloro-2-phenylpyrimidine {} {} {} {} {LY} 4,6-Dichloro-2-phenylpyrimidine {} {} {} {} {} {LY} 4,6-Dichloro-2-phenylpyrimidine {} {} {} {} {} {} {LY} 4,6-Dichloro-2-phenylpyrimidine {} {} {} {} {} {} {} {LY} 4,6-Dichloro-2-phenylpyrimidine {} {} {} {} {} {} {} {} {LY} 4,6-Dichloro-2-phenylpyrimidine {} {} {} {} {} {} {} {} {} {LY} 4,6-Dichloro-2-phenylpyrimidine {} {} {} {} {} {} {} {} {} {} {LY} 4,6-Dichloro-2-phenylpyrimidine {} {} {} {} {} {} {} {} {} {} {} {LY} 4,6-Dichloro-2-phenylpyrimidine {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4,6-Dichloro-2-phenylpyrimidine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4,6-Dichloro-2-phenylpyrimidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4,6-Dichloro-2-phenylpyrimidine {} {} {} {}
PubChem Substance ID77338
Beilstein Registry Number142293
Reaxys-RN142293
Chemical Name Translation4,6-二氯-2-苯基-嘧啶
LabNetwork Molecule IDLN00009929
InChIInChI=1S/C10H6Cl2N2/c11-8-6-9(12)14-10(13-8)7-4-2-1-3-5-7/h1-6H
Canonical SMILESC2=C(C1=NC(=CC(=N1)Cl)Cl)C=CC=C2
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分类

  • {KO} ReacChlorides
  • {SNA} All alphabetically sorted, Alphabetic, Analytical Standards, Analytical/Chromatography, Chromatography, E-G, Environmental Standards, F, FA - FL, Pesticides & Metabolites
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Chromatography, E-G, Environmental Standards,
  • {SNA} All alphabetically sorted, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chromatography, E-G, Environmental Standards, F, FA - FL, Pesticides & Metabolites
  • {SNA} Alphabetical Index of Analytical Standards,

产品应用

  • 一种安全剂,与丙草胺同时使用。

相关文献及参考

  • Lee, H., et al.: Eur. J. Med. Chem., 40, 862 (2005),
  • Wright, S., et al.: Bioorg. Med. Chem. Lett., 17, 5638 (2007),

安全信息

Warnings IRRITANT
Hazard Codes Xn
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
Risk Statements
  • R20 Harmful by inhalation 吸入有害
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
RTECSUV8258400
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P302+P352+P332+P313+P362+P364
  • P304+P312
  • P304+P340
  • P304+P340+P312
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P305+P354+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P317
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P332+P313
  • P333+P313
  • P333+P317
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H318 Causes serious eye damage 严重伤害眼睛
  • H332 Harmful if inhaled 吸入有害
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
WGK Germany2
Signal word Danger Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Packing GroupIII
Hazard Class9
UN Number 3077
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2900 mg/m3/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PEMNDP Pesticide Manual.  (The British Crop Protection Council, 20 Bridport
   Rd., Thornton Heath CR4 7QG, UK)  V.1-    1968-  Volume(issue)/page/year:
   9,366,1991

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson
   Publications, 1976/77 revision  Volume(issue)/page/year: 3,124,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - quail
DOSE/DURATION           : >500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PEMNDP Pesticide Manual.  (The British Crop Protection Council, 20 Bridport
   Rd., Thornton Heath CR4 7QG, UK)  V.1-    1968-  Volume(issue)/page/year:
   9,366,1991

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PEMNDP Pesticide Manual.  (The British Crop Protection Council, 20 Bridport
   Rd., Thornton Heath CR4 7QG, UK)  V.1-    1968-  Volume(issue)/page/year:
   9,366,1991

Storage condition -20°C, sealed storage, away from moisture {LY} -20°C, sealed storage, away from moisture 2-8°C {} {LY} -20°C, sealed storage, away from moisture {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moi

药物吸收、分布、代谢与排泄(ADME)

Lipinski's Rule of 5
Y
H-bond Acceptors
2
Rotatable Bonds
1
H-bond Donors
0
LogP
3

其他信息

  • 用途一:属安全性除草剂
  • 用途二:一种安全剂,与丙草胺同时使用。
  • 溶于丙酮、环己酮、二氯甲烷、甲苯、二甲苯,微溶于己烷、甲醇、正辛醇、异丙醇。
  • MOL 文件:3740-92-9.mol
  • Sigma Aldrich:3740-92-9(sigmaaldrich)

系列性分类


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