(1R,3s,5S)-3-((3-hydroxy-2-phenylpropanoyl)oxy)-8-isopropyl-8-methyl-8-azabicyclo[3.2.1]octan-8-ium bromide 异丙托溴铵

CAS 22254-24-6 MFCD00069291

化学结构图

22254-24-6
SMILES: [Br-].CC(C)[N+]1(C)[C@@H]2C[C@H](C[C@H]1CC2)OC(=O)C(CO)C1C=CC=CC=1 |&1:6,8,10|

化学属性

Mol. FormulaC20H30BrNO3
Mol. Weight412.37
TSCANo
Melting Point229-231°

别名和识别编码

Chemical Name(1R,3s,5S)-3-((3-hydroxy-2-phenylpropanoyl)oxy)-8-isopropyl-8-methyl-8-azabicyclo[3.2.1]octan-8-ium bromide
MDL NumberMFCD00069291
Synonym (endo,syn)-(±)-3-(3-Hydroxy-1-oxo-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]
EC Number244-873-8
CAS Number22254-24-6
Merck Number14,5073
Chemical Name Translation异丙托溴铵
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相关文献及参考

  • [2]. Harvey, K.L., A. Hussain, and H.L. Maddock, Ipratropium Bromide-Mediated Myocardial Injury in In Vitro Models of Myocardial Ischaemia/Reperfusion. Toxicol Sci, 2014.
  • [3]. Maria Prat, et al. Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl amides as potent and long acting muscarinic antagonists. Bioorg Med Chem Lett. 2015 Apr 15;25(8):1736-1741.
  • [4]. Wenhui Zhang, et al. Anti-inflammatory effects of formoterol and ipratropium bromide against acute cadmium-induced pulmonary inflammation in rats. Eur J Pharmacol. 2010 Feb 25;628(1-3):171-8.
  • [1]. Fryer, A.D. and J. Maclagan, Ipratropium bromide potentiates bronchoconstriction induced by vagal nerve stimulation in the guinea-pig. Eur J Pharmacol, 1987. 139(2): p. 187-91.
  • [1]. Fryer, A.D. and J. Maclagan, Ipratropium bromide potentiates bronchoconstriction induced by vagal nerve stimulation in the guinea-pig. Eur J Pharmacol, 1987. 139(2): p. 187-91.
  • [2]. Harve

安全信息

RTECSYM3700000
Safety Statements
  • S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R20 Harmful by inhalation 吸入有害
  • R36 Irritating to eyes 刺激眼睛
  • R22 Harmful if swallowed 吞咽有害

系列性分类

  1. Functional Group 官能团索引
  2. quaternary ammonium salt
  1. Medical Research Areas
  2. GPCR & G Protein
  3. mAChR  (毒蕈碱型乙酰胆碱受体)

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