Biperiden hydrochloride Biperiden
CAS 1235-82-1 MFCD00797516
化学结构图
SMILES: Cl.OC(CCN1CCCCC1)(c1ccccc1)C1C[C@@H]2C=C[C@H]1C2
化学属性
| Mol. Formula | C21H29NO.ClH |
|---|---|
| Mol. Weight | 347.97 |
别名和识别编码
| Chemical Name | Biperiden Hydrochloride |
|---|---|
| CAS Number | 1235-82-1 |
| Synonym | 1-(5-Bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidinyl)propan-1-ol hydrochloride 1-(5-Bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidinyl)propan-1-ol hydrochloride Akineton Akinophyl 1-Bicycloheptenyl-1-phenyl-3-piperidinopropanol-1 hydrochloride ?-5-Norbornen-2-yl-?-phenyl-1-piperidinepropanol Hydrochloride ?-Bicyclo[2.2.1]hept-5-en-2-yl-?-phenyl-1-piperidinepropanol Hydrochloride Akineton Akineton Hydrochloride Akineton hydrochloride Akinophyl Biperiden Biperiden Hydrochloride Biperiden 盐酸盐 Biperiden, 1R-(1 alpha,2 alpha(R*),4 alpha)-Isomer Biperiden, 1S-(1 alpha,2 alpha(R*),4 alpha)-Isomer Biperidene Biperidene Hydrochloride Hydrochloride, Biperiden alpha-(Bicyclo(2.2.1)hept-5-en-2-yl)-alpha-phenyl-1-piperidinepropanol alpha-Bicyclo(2.2.1)hept-5-en-2-yl-alpha-phenyl-1-piperidinepropa |
| EC Number | 214-976-2 |
| Chemical Name Translation | Biperiden |
| Wiswesser Line Notation | L55 A CUTJ FXQR&2- AT6NTJ &GH |
| PubChem Substance ID | 92151 |
| InChI | InChI=1S/C21H29NO.ClH/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17;/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2;1H |
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分类
- {SNA} Abbott, Adenosines/P2 Nucleotide Receptors (Purinergics), Antagonists, Approved Therapeutics/Drug Candidates, B, Neuroscience, Neurotransmi
- {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards, EP Standards A - B, Pharmaceutical Standards, Pharmacopeia Standards
- Heterocycles
- {SNA} Abbott, Adenosines/P2 Nucleotide Receptors (Purinergics), Antagonists, Approved Therapeutics/Drug Candidates, B, Bioactive Small Molecules, Cell Signaling and Neuroscience, Neuroscience, Neurotransmission, Neurotransmitters, 细胞生物学
- {SNA} Analytica
产品应用
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相关文献及参考
- [2]. Kornhuber J, et al. Identification of novel functional inhibitors of acid sphingomyelinase. PLoS One. 2011;6(8)
- [3]. Myhrer T, et al. Antiparkinson drugs used as prophylactics for nerve agents: studies of cognitive side effects in rats. Pharmacol Biochem Behav. 2008 Jun;89(4):633-8.
- Bebawy, L., et al: J. Pharm. Biomed. Anal., 20, 663 (1999),
- Dinc, E., et al.: J. Pharm. Biomed. Anal., 28, 591 (2002),
- Patela, Y., et al.: Talanta, 47, 625 (1998),
- [1]. Pehl C, et al. Effects of two anticholinergic drugs, trospium chloride and biperiden, on motility and evoked potentials of the oesophagus. Aliment Pharmacol Ther. 1998 Oct;12(10)
- [1]. Pehl C, et al. Effects of two anticholinergic drugs, trospium chloride and biperiden, on motility and evoked potentials of the oesophagus. Aliment Pharmacol Ther. 1998 Oct;12(10)
- [2]. Kornhuber J, et al. Identification of novel functional inhibitors of acid sphingomyelinase. PLoS One. 2011;6(
安全信息
- R22 Harmful if swallowed 吞咽有害
GHS Symbol
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
- P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P312
- P304+P312
- P304+P340
- P305+P351+P338
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
- P330 Rinse mouth. 漱口
- P337+P313
- P370+P378
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H228 Flammable solid 易燃固体
- H302 Harmful if swallowed 吞食有害
- H319 Causes serious eye irritation 严重刺激眼睛
- H332 Harmful if inhaled 吸入有害
- H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 530 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 1,74,1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 750 mg/kg TOXIC EFFECTS : Behavioral - food intake (animal) Behavioral - fluid intake Behavioral - muscle weakness REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,379,1960
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 340 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - muscle weakness REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,379,1960
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 56 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,192,1989
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