LY364947 4-(3-吡啶-2-基-1H-吡唑-4-基)喹啉

CAS 396129-53-6 MFCD00800758

化学结构图

396129-53-6
SMILES: C1NN=C(C=1C1=CC=NC2C=CC=CC=21)C1=CC=CC=N1

化学属性

Mol. FormulaC17H12N4
Mol. Weight272
Melting Point>230°(dec)

别名和识别编码

Chemical NameLY364947
CAS Number396129-53-6
Alfabeta NamePYRIDINYLPYRAZOLYLQUINOLINE H43214()--------
MDL NumberMFCD00800758
Synonym 4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-quinoline 4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-quinoline HTS 466284 Transforming Growth Factor-β Type I Receptor Kinase Inhibitor HTS 466284 LY-364947 Transforming Growth Factor-β Type I Receptor Kinase Inhibitor Transforming Growth Factor-β Type I Receptor Kinase Inhibitor
PubChem Substance ID24724526
Chemical Name Translation4-(3-吡啶-2-基-1H-吡唑-4-基)喹啉
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分类

  • {SNA} Bioactive Small Molecule Alphabetical Index,
  • {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones, Kinase/Phosphatase Biology, L,
  • {SA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines and Growth Factors, Cytokines, Growth Factor

相关文献及参考

  • Sawyer, J.S., et al., Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I J. Med. Chem. 46 , 3953-3956, (2003) 摘要
  • Singh, J., et al., Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI) Bioorg. Med. Chem. Lett. 13 , 4355-4359, (2003) 摘要
  • Li, H., et al., Dihydropyrrolopyrazole Transforming Growth Factor-β‚ Type I Receptor Kinase Domain Inhibitors: A Novel Benzimidazole Series with Selectivity versus Transforming Growth Factor-β‚ Type II Receptor Kinase and Mixed Lineage Kinase-7 J. Med. Chem. 49 , 2138-2142, (2006) 摘要
  • Shiou, S-R., et al., Smad4-dependent Regulation of Urokinase Plasminogen Activator Secretion and RNA Stability Associated with Invasiveness by Autocrine and Paracrine Transforming Growth Factor-β J. Biol. Chem. 281 , 33971-33981, (2006) 摘要

安全信息

GHS Symbol
WGK Germany3
Hazard Codes T,N
Hazard statements
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H301 Toxic if swallowed 吞食有毒
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Precautionary statements
  • P301+P310
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Signal word Danger
Safety Statements
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R50/53

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Cytokines and Growth Factors - Cytokines, Growth Factors and Hormones
  6. Transforming Growth Factor-β (TGF-β) and Superfamily - Cytokines and Growth Factors
  7. TGF-β Inhibitors - Transforming Growth Factor-β (TGF-β) and Superfamily

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