6-((3-Chlorophenyl)(1H-imidazol-1-yl)methyl)-1H-benzo[d]imidazole 6-((3-氯苯基)(1H-咪唑-1-基)甲基)-1H-苯并[d]咪唑

CAS 115575-11-6 MFCD00864664

化学结构图

115575-11-6
SMILES: ClC1C=C(C=CC=1)C(C1=CC2N=CNC=2C=C1)N1C=NC=C1

化学属性

Mol. FormulaC17H13ClN4
Mol. Weight308.771

别名和识别编码

Chemical Name6-((3-Chlorophenyl)(1H-imidazol-1-yl)methyl)-1H-benzo[d]imidazole
Chemical Name Translation6-((3-氯苯基)(1H-咪唑-1-基)甲基)-1H-苯并[d]咪唑
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相关文献及参考

  • [2]. Lucker GP, et al. Oral treatment of ichthyosis by the cytochrome P-450 inhibitor liarozole. Br J Dermatol. 1997;136(1):71-75.
  • [3]. Wouters W, et al. Effects of liarozole, a new antitumoral compound, on retinoic acid-induced inhibition of cell growth and on retinoic acid metabolism in MCF-7 human breast cancer cells. Cancer Res. 1992;52(10):2841-2846.
  • [4]. Pignatello MA, et al. Liarozole markedly increases all trans-retinoic acid toxicity in mouse limb bud cell cultures: a model to explain the potency of the aromatic retinoid (E)-4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylenyl)-1-propenyl] benzoic acid. Toxicol Appl Pharmacol. 2002; 178(3):186-194.
  • [5]. Van Wauwe J, et al. Liarozole, an inhibitor of retinoic acid metabolism, exerts retinoid-mimetic effects in vivo. J Pharmacol Exp Ther. 1992;261(2):773-779.
  • [6]. Stearns ME, et al. Liarozole and 13-cis-retinoic acid anti-prostatic tumor activity [published correction appear

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Cytochrome P450  (细胞色素P450)
  1. Medical Research Areas
  2. Metabolism
  3. RAR/RXR  (维甲酸受体)

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