2-Amino-7-Isopropyl-5-Oxo-5H-Chromeno[2,3-b]Pyridine-3-Carboxylic Acid 2-氨基-7-异丙基-5-氧代-5H-苯并吡喃并[2,3-b]吡啶-3-羧酸

CAS 68302-57-8 MFCD00864790

化学结构图

68302-57-8
SMILES: CC(C)C1=CC2=C(C=C1)OC1=NC(N)=C(C=C1C2=O)C(O)=O

化学属性

Mol. FormulaC16H14N2O4
Mol. Weight298.29
Melting Point300

别名和识别编码

Chemical Name2-Amino-7-Isopropyl-5-Oxo-5H-Chromeno[2,3-b]Pyridine-3-Carboxylic Acid
CAS Number68302-57-8
Synonym Elics Amoxanox 2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic Acid Aphthasol 2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]Benzopyrano[2,3-b]pyridine-3-carboxylic acid AA 673 Amoxanox CHX 3673 2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]Benzopyrano[2,3-b]pyridine-3-carboxylic acid Amlexanox Solfa CHX-3673 2-​Amino-​7-​(1-​methylethyl)​-​5-​oxo-​5H-​[1]​Benzopyrano[2,3-​b]​pyridine-​3-​carboxylic acid
MDL NumberMFCD00864790
Beilstein Registry Number556384
Chemical Name Translation2-氨基-7-异丙基-5-氧代-5H-苯并吡喃并[2,3-b]吡啶-3-羧酸
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分类

  • Pharmaceuticals
  • {SNA} Cell Biology, Cell Signaling and Neuroscience, Immune Cell Signaling, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics, New Products
  • Intermediates & Fine Chemicals,
  • {SNA} A-AM, Bioactive Small Molecule Alphabetical Index, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学

产品应用

  • Inhibits release of allergic mediators from mast cells. Antiallergic; antiasthmatic.

相关文献及参考

  • Rankov, G., et al.: Ophthalmic Res., 22, 359 (1990),
  • Greer, R.O., et al.: J. Oral Mxillofac. Surg., 51, 243 (1993),

安全信息

RTECSDJ3102000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2320 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 13,6405,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 13,6405,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 13,6405,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed acti

GHS Symbol
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
WGK Germany3
Signal word
Hazard Codes Xn
Risk Statements
Precautionary statements

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Immune Cell Signaling and Blood - Cell Signaling and Neuroscience
  5. Immune System Regulation - Immune Cell Signaling and Blood
  6. Immunomodulators and Antibiotics - Immune System Regulation

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