5-(4-((1-Methylcyclohexyl)Methoxy)Benzyl)Thiazolidine-2,4-Dione 环格列酮

CAS 74772-77-3 MFCD00865499

化学结构图

74772-77-3
SMILES: CC1(COC2=CC=C(CC3SC(=O)NC3=O)C=C2)CCCCC1

化学属性

Mol. FormulaC18H23NO3S
Mol. Weight333

别名和识别编码

Chemical Name5-(4-((1-Methylcyclohexyl)Methoxy)Benzyl)Thiazolidine-2,4-Dione
CAS Number74772-77-3
Synonym (±)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione (±)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione Ciglitazone (+/-)-5-[4-(1-methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione ADD 3878 ADD-3878 Ciglitazone Ciglitizone U 63287
MDL NumberMFCD00865499
PubChem Substance ID24892661
Chemical Name Translation环格列酮
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分类

  • Sulfur & Selenium Compounds
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, CI-CZ, Gene Regulation, Gene Regulation and Expression, PPAR and RXR Regulators, Takeda, 抗肿瘤药物, 生物活性小分子, 癌症研究, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Antitumor Agents, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, CI-CY, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Gene Regulation, Gene Regulation and Expression, PPAR and RXR Regulators, Takeda

产品应用

  • Displays antihyperglycemic activity in genetically obese mice. It is a selective PPARg agonist.

相关文献及参考

  • Clark, D.A., et al.: J. Med. Chem., 34, 319-325 (1991); Sohda, T., et al.: Chem. Pharm. Bull., 30(10), 3580-3600, (1982)

安全信息

WGK Germany3
RTECSXJ5813700
Personal Protective Equipment Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US) 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 950 mg/kg
SEX/DURATION            : female 1-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   SEIJBO Senten Ijo.  Congenital Anomalies.  (Nippon Senten Ijo Gakkai, c/o
   Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
   Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
   information, see CGANE7.  Volume(issue)/page/year: 26,169,1986

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Gene Regulation and Expression - Cell Signaling and Neuroscience
  5. PPAR and RXR Regulators - Gene Regulation and Expression
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Gene Regulation and Expression - Cell Signaling and Neuroscience
  5. PPAR and RXR Regulators - Gene Regulation and Expression

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