(S)-2-(N-((2’-(1H-Tetrazol-5-yl)-[1,1’-Biphenyl]-4-yl)Methyl)Pentanamido)-3-Methylbutanoic Acid (S)-2-(N-(((2’-(1H-四唑-5-基)-[1,1’-联苯]-4-基)甲基)戊酰胺基)-3-甲基丁酸

CAS 137862-53-4 MFCD00865840

化学结构图

137862-53-4
SMILES: [2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C(=O)N(CC1=CC=C(C=C1)C1=CC=CC=C1C1NN=NN=1)[C@@H](C(C)C)C(O)=O

化学属性

Mol. FormulaC24H29N5O3
Mol. Weight435.53
Melting Point116-117

别名和识别编码

Chemical Name(S)-2-(N-((2’-(1H-Tetrazol-5-yl)-[1,1’-Biphenyl]-4-yl)Methyl)Pentanamido)-3-Methylbutanoic Acid
CAS Number137862-53-4
Alfabeta NameTETRAZOLYLBIPHENYLYLMETHYLPENTANAMIDOMETHYLBUTANOICACID SNH22151143[]((((()))))-------------,''
MDL NumberMFCD00865840
Synonym N-Valeryl-N-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-L-valine
Chemical Name Translation(S)-2-(N-(((2’-(1H-四唑-5-基)-[1,1’-联苯]-4-基)甲基)戊酰胺基)-3-甲基丁酸
PubChem Substance ID125307697
Reaxys-RN7754038
Merck Number9916
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分类

  • {SNA} Angiotensin Receptor Antagonists, Angiotensins, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Novartis, Peptides and Proteins, Peptides for Cell Biology, V, 生化试

相关文献及参考

  • [2]. Wang Y, et al. Valsartan blocked alcohol-induced, Toll-like receptor 2 signaling-mediated inflammation in human vascular endothelial cells. Alcohol Clin Exp Res. 2014 Oct;38(10):2529-40.
  • [3]. Sui X, et al. Novel mechanism of cardiac protection by valsartan: synergetic roles of TGF-β1 and HIF-1α in Ang II-mediated fibrosis after myocardial infarction. J Cell Mol Med. 2015 Aug;19(8):1773-82.
  • [4]. Jiang Y, et al. Cardioprotective effect of valsartan in mice with short-term high-salt diet by regulating cardiac aquaporin 1 and angiogenic factor expression. Cardiovasc Pathol. 2015 Jul-Aug;24(4):224-9.
  • [5]. Ping G, et al. Valsartan reverses depressive/anxiety-like behavior and induces hippocampal neurogenesis and expression of BDNF protein in unpredictable chronic mild stress mice. Pharmacol Biochem Behav. 2014 Sep;124:5-12.
  • [1]. Shan H, et al. Valsartan ameliorates ageing-induced aorta degeneration via angiotensin II type 1 receptor-mediated

安全信息

Warnings IRRITANT
WGK Germany3
GHS Symbol
Safety Statements
Risk Statements
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P308+P313
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
RTECSYV9455000
Signal word

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Approved Therapeutics/Drug Candidates - Cell Signaling and Neuroscience
  5. Novartis - Approved Therapeutics/Drug Candidates
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Angiotensin Receptor  (血管紧张素受体)

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