Tamibarotene 他米巴罗汀
CAS 94497-51-5 MFCD00866188
化学结构图
SMILES: CC1(C)CCC(C)(C)C2C=C(C=CC1=2)NC(=O)C1C=CC(=CC=1)C(O)=O
化学属性
| Mol. Formula | C22H25NO3 |
|---|---|
| Mol. Weight | 351.44 |
| TSCA | No |
别名和识别编码
| Chemical Name | Tamibarotene |
|---|---|
| CAS Number | 94497-51-5 |
| Alfabeta Name | TETRAMETHYLTETRAHYDRONAPHTHALENYLCARBAMOYLBENZOICACID 4558856782(())------,,,,,, |
| MDL Number | MFCD00866188 |
| Synonym | 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]benzoic Acid Tamibarotene AM 80 -((5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl)benzoic acid 4-(((5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino)carbonyl)-benzoic acid AM 80 AM80 AMNOLAKE Amnoid N-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl)-2-naphthyl)terephthalamic acid N-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)terephthalamic acid NSC 608000 UNII-08V52GZ3H9 |
| Merck Number | 14,9047 |
| Chemical Name Translation | 他米巴罗汀 |
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分类
- Pharmaceuticals
- {SNA} Cell Biology, Cell Signaling and Neuroscience, Gene Regulation and Expression, PPAR and RXR Regulators
- Retinoids,
- Intermediates & Fine Chemicals
- {SNA} Bioactive Small Molecule Alphabetical Index, Gene Regulation and Expression, PPAR and RXR Regulators, T, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
产品应用
- Synthetic retinoic acid receptor-?/?-selective retinoid. Antineoplastic.
相关文献及参考
- [2]. Toyama T, et al. Tamibarotene Ameliorates Bleomycin-Induced Dermal Fibrosis by Modulating Phenotypes of Fibroblasts, Endothelial Cells, and Immune Cells. J Invest Dermatol. 2016 Feb;136(2):387-98.
- [3]. Jin Y, et al. Tamibarotene modulates the local immune response in experimental periodontitis. Int Immunopharmacol. 2014 Dec;23(2):537-45.
- [4]. Lv XR, et al. Synthetic retinoid Am80 up-regulates apelin expression by promoting interaction of RARα with KLF5 and Sp1 in vascular smooth muscle cells. Biochem J. 2013 Nov 15;456(1):35-46.
- [5]. Kitaoka K, et al. The retinoic acid receptor agonist Am80 increases hippocampal ADAM10 in aged SAMP8 mice. Neuropharmacology. 2013 Sep;72:58-65.
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- Shinjo, K., et al.: Int. J. Hematol., 72, 470 (2000),
- [1]. Wang X, et al. Retinoic acid receptor alpha drives cell cycle progres
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