Batimastat (2S,3R)-N1-羟基-3-异丁基-N4-((S)-1-(甲基氨基)-1-氧代-3-苯基丙-2-基)-2-((噻吩-2-基硫代)甲基)琥珀酰胺
CAS 130370-60-4 MFCD00866533
化学结构图
SMILES: CC(C)C[C@H]([C@H](CSC1=CC=CS1)C(=O)NO)C(=O)N[C@@H](CC1C=CC=CC=1)C(=O)NC
化学属性
| Mol. Formula | C23H31N3O4S2 |
|---|---|
| Mol. Weight | 477.64 |
别名和识别编码
| Chemical Name | (BB-94) Batimastat |
|---|---|
| Synonym | BB-94; (2R,3S)-N4-Hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide Batimastat |
| MDL Number | MFCD00866533 |
| PubChem Substance ID | 329825111 |
| Chemical Name Translation | (2S,3R)-N1-羟基-3-异丁基-N4-((S)-1-(甲基氨基)-1-氧代-3-苯基丙-2-基)-2-((噻吩-2-基硫代)甲基)琥珀酰胺 |
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {SNA} B, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix, Extracellular Matrix, Metalloproteinase Inhibitors
- {SNA} B, Bioactive Small Molecule Alphabetical Index, Cytoskeleton and Extracellular Matrix, Extracellular Matrix, Metalloproteinase Inhibitors, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
相关文献及参考
- [2]. Botos I, et al. Batimastat, a potent matrix mealloproteinase inhibitor, exhibits an unexpected mode of binding. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2749-54.
- [3]. Hansen HP, et al. Inhibition of metalloproteinases enhances the internalization of anti-CD30 antibody Ki-3 and the cytotoxic activity of Ki-3 immunotoxin. Int J Cancer. 2002 Mar 10;98(2):210-5.
- [4]. Giavazzi R, et al. Batimastat, a synthetic inhibitor of matrix metalloproteinases, potentiates the antitumor activity of cisplatin in ovarian carcinoma xenografts. Clin Cancer Res. 1998 Apr;4(4):985-92.
- [5]. Ricci S, et al. Inhibition of matrix metalloproteinases attenuates brain damage in experimental meningococcal meningitis. BMC Infect Dis. 2014 Dec 31;14:726.
- [6]. Russo LA, et al. Regulated expression of matrix metalloproteinases, inflammatory mediators, and endometrial matrix remodeling by 17beta-estradiol in the immature rat uterus. Reprod Biol Endocrinol. 2009 Nov 4
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
京ICP备2020036287号