Haloxazolam

CAS 59128-97-1 MFCD00868022

化学结构图

59128-97-1
SMILES: O=C1CN2CCOC2(C2C=C(Br)C=CC=2N1)C1C=CC=CC=1F

化学属性

Mol. FormulaC17H14BrFN2O2
Mol. Weight377.24

别名和识别编码

Chemical NameOxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one,2,3,7,11b-tetrahydro-10-bromo-11b-(2-fluoro phenyl)-
CAS Number59128-97-1
Synonym CS-430 10-Bromo-11b-(2-fluorophenyl)-2,3,7,11b-tetrahydrooxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one Haloxazolam CS 430 10-Bromo-11b-(2-fluorophenyl)-2,3,7,11b-tetrahydrooxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one Somelin
Beilstein Registry Number0569670
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分类

  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Sleep-inducing agent, related structurally to Oxazolam and Cloxazolam (C587475).

相关文献及参考

  • Miyadera, T., et al.: J. Med. Chem., 14, 520, (1971),
  • Yoshimoto, M., et al.: Chem. Pharm. Bull., 25, 1378 (1977),

安全信息

RTECSRQ5831500 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YAKUD5 Gekkan Yakuji.  Pharmaceuticals Monthly.  (Yakugyo Jihosha, Inaoka
   Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-   1959-
   Volume(issue)/page/year: 22,1501,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2858 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   SKKNAJ Sankyo Kenkyusho Nempo.  Annual Report of Sankyo Research
   Laboratories.  (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku,
   Tokyo 140, Japan)  No.15-    1963-  Volume(issue)/page/year: 27,64,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >15 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YAKUD5 Gekkan Yakuji.  Pharmaceuticals Monthly.  (Yakugyo Jihosha, Inaoka
   Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-   1959-
   Volume(issue)/page/year: 22,1501,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YAKUD5 Gekkan Yakuji.  Pharmaceuticals Monthly.  (Yakugyo Jihosha, Inaoka
   Bldg., 2

TYPE OF TEST            : LD50 - Lethal dose, 50 perce

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 3600 mg/kg
SEX/DURATION            : female 1-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   SKKNAJ Sankyo Kenkyusho Nempo.  Annual Report of Sankyo Research
   Laboratories.  (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku,
   Tokyo 140, Japan)  No.15-    1963-  Volume(issue)/page/year: 27,64,1975

Restrict 精麻类化学品

系列性分类

  1. Functional Group 官能团索引
  2. hemiaminal

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