Cloxazolam

CAS 24166-13-0 MFCD00868152

化学结构图

24166-13-0
SMILES: O=C1CN2CCOC2(C2C=C(Cl)C=CC=2N1)C1C=CC=CC=1Cl

化学属性

Mol. FormulaC17H14Cl2N2O2
Mol. Weight349.23

别名和识别编码

Chemical NameOxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one,10-chloro-11b-(o-chlorophenyl)-2,3,7,11b- tetrahydro-
CAS Number24166-13-0
Synonym Tolestan Olcadil Lubalix Cloxazolazepam Cloxazolam Sepazone Betavel 10-Chloro-11b-(2-chlorophenyl)-2,3,7,11b-tetrahydrooxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one Sepazon CS 370 MT 14-411 Enadel
Wiswesser Line NotationT B576 CO FN HVMTT&J BR BG& MG
Beilstein Registry Number0569691
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分类

  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • A benzodiazepine derivative with anxiolytic, hypnotic and antihypertensive properties used as an anti-anxiety drug. It is metabolized into the active metabolite Delorezepam (D230675).

相关文献及参考

  • Oliveira-Silva, D. et al.: Biomed. Chrom., 23, 1266 (2009); Kamioka, T. et al.: Psychopharmacol., 52, 17 (1977); Fischer-Cornelssen, K.A. et al.: Arzneim.-Forsch., 31, 1757 (1981);

安全信息

RTECSRQ5831350 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 5,106,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >6 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 5,106,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2630 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 5,106,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 5,106,1974

TYPE OF TEST            : LD50 - Le

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1800 mg/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   SKKNAJ Sankyo Kenkyusho Nempo.  Annual Report of Sankyo Research
   Laboratories.  (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku,
   Tokyo 140, Japan)  No.15-    1963-  Volume(issue)/page/year: 23,180,1971

Restrict 精麻类化学品

系列性分类

  1. Functional Group 官能团索引
  2. hemiaminal

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