N-[4-(2-{2-[4-(methanesulphonamido)phenoxyl]-N-methylethylamino}ethyl)phenyl]-methanesulphonamide N-[4-(2-{2-[4-(甲磺酰胺基)苯氧基]-N-甲基乙基氨基}乙基)苯基]-甲磺酰胺

CAS 115256-11-6 MFCD00869707

化学结构图

115256-11-6
SMILES: CS(=O)(=O)NC1C=CC(=CC=1)OCCN(C)CCC1C=CC(=CC=1)NS(C)(=O)=O

化学属性

Mol. FormulaC19H27N3O5S2
Mol. Weight441.56

别名和识别编码

Chemical NameN-[4-(2-{2-[4-(methanesulphonamido)phenoxyl]-N-methylethylamino}ethyl)phenyl]-methanesulphonamide
Synonym Dofetilida Dofetilide Dofetilidum N-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]methanesulfonamide N-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]methanesulfonamide UK-68798 UK-68798 beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide
MDL NumberMFCD00869707
Chemical Name TranslationN-[4-(2-{2-[4-(甲磺酰胺基)苯氧基]-N-甲基乙基氨基}乙基)苯基]-甲磺酰胺
CAS Number115256-11-6
PubChem Substance ID329823685
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分类

  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DIG-DY, Ion Channels, Monovalent Ion Channels, Pfizer Compounds, Potassium Channel Modulators, Voltage-gated Ion Channels
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index,

安全信息

Safety Statements
  • S57 Use appropriate containment to avoid environmental contamination 使用适当容器避免环境污染；
  • S22 Do not breathe dust 不要吸入粉尘；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
GHS Symbol
Precautionary statements
  • P305+P351+P338
  • P308+P313
  • P201 Obtain special instructions before use. 使用前获取专门指示。
Hazard statements
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
WGK Germanynwg
Signal word Danger
Hazard Codes T,N
Risk Statements
  • R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
  • R51 Toxic to aquatic organisms 对水生生物有毒
  • R48/22
RTECSPB0478000 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 11025 ug/kg
SEX/DURATION            : female 13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 53,168,1996

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 22050 ug/kg
SEX/DURATION            : female 11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 53,168,1996

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 44100 ug/kg
SEX/DURATION            : female 14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 53,168,1996

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. DIG-DY - Bioactive Small Molecules

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