2-Ethoxy-1-[(2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-7-benzimidazolecarboxylic acid 1-(cyclohexyloxycarbonyloxy)ethyl ester 2-乙氧基-1-[[2'-(1H-四氮唑-5-基)[1,1'-联苯基]-4-基]甲基]-1H-苯并咪唑-7-甲酸-1-[[(环己氧基)羰基]氧基]乙酯

CAS 145040-37-5 MFCD00871371

化学结构图

145040-37-5
SMILES: [2H]C1(OC(=O)OC(C)OC(=O)C2=CC=CC3N=C(OCC)N(CC4C=CC(=CC=4)C4=CC=CC=C4C4NN=NN=4)C=32)C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C1([2H])[2H]

化学属性

Mol. FormulaC33H34N6O6
Mol. Weight611
Melting Point157-163

别名和识别编码

Chemical Name2-Ethoxy-1-[(2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-7-benzimidazolecarboxylic acid 1-(cyclohexyloxycarbonyloxy)ethyl ester
CAS Number145040-37-5
Alfabeta NameCYCLOHEXYLOXYCARBONYLOXYETHYLTETRAZOLYLBIPHENYLYLMETHYLETHOXYBENZOIMIDAZOLECARBOXYLATE HHD11225114217[[]](((((())))))----------------,''
MDL NumberMFCD00871371
Synonym 1-​(4-​chlorobenzoyl)​-​5-​methoxy-​2-​methyl-1H-​indole-​3-​acetic acid carboxymethyl ester 2-ethoxy-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-Benzimidazole-7-carboxylic acid 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester 2-ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-Benzimidazole-7-carboxylic acid 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester TCV 116 TCY 116 Candesartan cilexetil TCV 116
Reaxys-RN7328188
Merck Number1739
Chemical Name Translation2-乙氧基-1-[[2'-(1H-四氮唑-5-基)[1,1'-联苯基]-4-基]甲基]-1H-苯并咪唑-7-甲酸-1-[[(环己氧基)羰基]氧基]乙酯
PubChem Substance ID160871141
Beilstein Registry Number7328188
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分类

  • {SNA} Angiotensin Receptor Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, C-CH, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Proteins and Derivatives,
  • {SNA} Angiotensin Receptor Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, C-CH, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Takeda, 生化试剂, 生物活性小分子, 细胞生物学, 蛋白质及衍生物
  • Angiotensin Receptor Antagonists, Approved

相关文献及参考

  • [2]. Wada, T., et al., Comparison of the antihypertensive effects of the new angiotensin II (AT1) receptor antagonist candesartan cilexetil (TCV-116) and the angiotensin converting enzyme inhibitor enalapril in rats. Hypertens Res, 1996. 19(2): p. 75-81.
  • Mizuno K, Niimura S, Tani M, Saito I, Sanada H, et al., Hypotensive activity of TCV-116, a newly developed angiotensin II receptor antagonist, in spontaneously hypertensive rats. Life Sci. 20 , PL183-7, (1992)
  • Sachinidis A, el-Haschimi K, Ko Y, Seul C, Düsing R, Vetter H., CV-11974, the active metabolite of TCV-116 (Candesarten), inhibits the synergistic or additive effect of different growth factors on angiotensin II-induced proliferation of vascular smooth muscle cells. Biochem. Pharmacol. 1 , 123-6, (1996)
  • [1].
  • [1]. Pfeffer, M.A., et al., Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme. Lancet, 2003. 362(9386): p. 759-66.

安全信息

Warnings IRRITANT
GHS Symbol
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P263 Avoid contact during pregnancy/while nursing. 怀孕/哺乳期间避免接触。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P308+P313
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Hazard statements
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
WGK Germany3
RTECSDD6672500
Storage condition 0-10 0-10°C
Safety Statements
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
Hazard Codes 9 T,N
Risk Statements
  • R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
  • R48/20
  • R50 Very toxic to aquatic organisms 对水生生物极毒
UN Number 3077
Packing GroupIII

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Proteins and Derivatives - Biochemicals and Reagents
  4. Membrane Protein Biology Tools - Proteins and Derivatives
  5. GPCR Proteins, Modulators and Antibodies - Membrane Protein Biology Tools
  6. GPCR Modulators - GPCR Proteins, Modulators and Antibodies
  7. Angiotensin Receptor Antagonists - GPCR Modulators
  1. Functional Group 官能团索引
  2. carbonic acid diester
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Angiotensin Receptor  (血管紧张素受体)

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