Losartan Carboxylic Acid 1-((2’-(1H-四唑-5-基)-[1,1’-联苯]-4-基)甲基)-2-丁基-4-氯-1H-咪唑-5-羧酸
CAS 124750-92-1 MFCD00871928
化学结构图
SMILES: CCCCC1=NC(Cl)=C(C(O)=O)N1CC1C=CC(=CC=1)C1C=CC=CC=1C1=NNN=N1
化学属性
| Mol. Formula | C22H21ClN6O2 |
|---|---|
| Mol. Weight | 437 |
| Melting Point | 130-132 |
别名和识别编码
| Chemical Name | Losartan Carboxylic Acid |
|---|---|
| Chemical Name Translation | 1-((2’-(1H-四唑-5-基)-[1,1’-联苯]-4-基)甲基)-2-丁基-4-氯-1H-咪唑-5-羧酸 |
| Synonym | EXP 3174 E-3174 2-Butyl-4-chloro-1-[[2-(1H-tetrazol-5-yl)[1,1-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid |
| CAS Number | 124750-92-1 |
| MDL Number | MFCD00871928 |
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相关文献及参考
- [2]. Inada Y, et al. Binding of KRH-594, an antagonist of the angiotensin II type 1 receptor, to cloned human and rat angiotensin II receptors. Fundam Clin Pharmacol. 2002 Aug;16(4):317-23.
- [3]. Richard V, et al. Comparison of the effects of EXP3174, an angiotensin II antagonist and enalaprilat on myocardial infarct size in anaesthetized dogs. Br J Pharmacol. 1993 Nov;110(3):969-74.
- [4]. Lynch JJ Jr, et al. EXP3174, the AII antagonist human metabolite of losartan, but not losartan nor the angiotensin-converting enzyme inhibitor captopril, prevents the development of lethal ischemic ventricular arrhythmias in a canine model of recent myocardial infarction. J Am Coll Cardiol. 1999 Sep;34(3):876-84.
- [1]. Sachinidis A, et al.
- [1]. Sachinidis A, et al. EXP3174, a metabolite of losartan (MK 954, DuP 753) is more potent than losartan in blockingthe angiotensin II-induced responses in vascular smooth muscle cells. J Hypertens. 1993 Feb;11(2):155-62.
安全信息
GHS Symbol
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 441 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 28,3959,1994
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