REMODULIN 曲前列尼尔钠
CAS 289480-64-4 MFCD00888847
化学结构图
SMILES: CCCCC[C@H](O)CC[C@@H]1[C@H]2CC3C=CC=C(OCC(O)=O)C=3C[C@H]2C[C@H]1O
化学属性
| Mol. Formula | C23H34O5 |
|---|---|
| Mol. Weight | 412.5018 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO |
别名和识别编码
| Chemical Name | Treprostinil sodium |
|---|---|
| Formula | C23H33NaO5 |
| Synonym | Treprostinil sodium; LRX 15; LRX-15; LRX15; BW 15AU; U-62840; Uniprost; Treprostinil; Orenitram; Remodulin. |
| IUPAC Name | Acetic acid, (((1R,2R,3aS,9aS)-2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-((3S)-3-hydroxyoctyl)-1H-benz(f)inden-5-yl)oxy)-, monosodium salt |
| InChIKey | IQKAWAUTOKVMLE-ZSESPEEFSA-M |
| InChI | InChI=1S/C23H34O5.Na/c1-2-3-4-7-17(24)9-10-18-19-11-15-6-5-8-22(28-14-23(26)27)20(15)12-16(19)13-21(18)25;/h5-6,8,16-19,21,24-25H,2-4,7,9-14H2,1H3,(H,26,27);/q;+1/p-1/t16-,17-,18+,19-,21+;/m0./s1 |
| Chemical Name Translation | 曲前列尼尔钠 |
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产品应用
- Treprostinil is a vasodilator that is used for the treatment of pulmonary arterial hypertension. Treprostinil is a synthetic analog of prostacyclin (PGI2). The inhaled form of treprostinil was approved by the FDA in July 2009 and is marketed as the trade name Tyvaso.
相关文献及参考
- [2]. Smadja DM, et al. Treprostinil indirectly regulates endothelial colony forming cell angiogenic properties by increasing VEGF-A produced by mesenchymal stem cells. Thromb Haemost. 2015 Oct;114(4):735-47.
- [3]. Ferrantino M, et al. Inhaled treprostinil sodium for the treatment of pulmonary arterial hypertension. Expert Opin Pharmacother. 2011 Nov;12(16):2583-93.
- [4]. Kazemi Z, et al. Repurposing Treprostinil for Enhancing Hematopoietic Progenitor Cell Transplantation. Mol Pharmacol. 2016 Jun;89(6):630-44.
- [5]. Ghonem N, et al. Treprostinil, a prostacyclin analog, ameliorates ischemia-reperfusion injury in rat orthotopic liver transplantation. Am J Transplant. 2011 Nov;11(11):2508-16.
- [6]. Nikam VS, et al. Treprostinil inhibits the recruitment of bone marrow-derived circulating fibrocytes in chronic hypoxic pulmonary hypertension. Eur Respir J. 2010 Dec;36(6):1302-14.
- [1]. Whittle BJ, et al. Binding and activity of the prostacycl
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