Blonanserin 布南色林
CAS 132810-10-7 MFCD00893838
化学结构图
SMILES: CCN1CCN(CC1)C1=CC(C2C=CC(F)=CC=2)=C2CCCCCCC2=N1
化学属性
| Mol. Formula | C23H30FN3 |
|---|---|
| Mol. Weight | 367.51 |
| Melting Point | 123.0 to 127.0 deg-C |
别名和识别编码
| Chemical Name | Blonanserin |
|---|---|
| CAS Number | 132810-10-7 |
| Synonym | 2-(4-Ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine AD 5423 Blonanserin Lonasen |
| MDL Number | MFCD00893838 |
| PubChem Substance ID | 253660431 |
| Chemical Name Translation | 布南色林 |
| Reaxys-RN | 9957203 |
| Merck Number | 1319 |
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分类
- Heterocycles
- {SNA} Antagonists, Approved Therapeutics/Drug Candidates, B, Bioactive Small Molecule Alphabetical Index, Dainippon Sumitomo, Diversification Ready Pharma-Developed Compounds, Neuroscience, Neurotransmission, Neurotransmitters, Serotonergics, 生物活性小分子, 细胞信号转导和
产品应用
- A 5-HT2 serotonin receptor and D2 dopamine receptor antagonist, used as an antipsychotic.
相关文献及参考
- [2]. Saori Takeuchi, et al. Blonanserin ameliorates social deficit through dopamine-D 3 receptor antagonism in mice administered phencyclidine as an animal model of schizophrenia. Neurochem Int. 2019 Sep;128:127-134.
- Ochi, T., et al.: Bioorg. Med. Chem., Lett., 15, 1055 (2005),
- Oka, T., et al.: Life Sci., 76, 225 (2004),
- Singh, A., et al.: Int. Med. J., 12, 175 (2005),
- [1]. Blonanserin
- [1]. Blonanserin
- [2]. Saori Takeuchi, et al. Blonanserin ameliorates social deficit through dopamine-D 3 receptor antagonism in mice administered phencyclidine as an animal model of schizophrenia. Neurochem Int. 2019 Sep;128:127-134.
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- H413 Maycauselonglastingharmfuleffectstoaquaticlife 可能对水生生物造成长期持续有害影响。
- R22 Harmful if swallowed 吞咽有害
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P301+P312+P330
- P501 Dispose of contents/container to..… 处理内容物/容器.....
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