2H,11H-Naphtho(2,1-b)pyrano(3,4-e)pyran-11-one,1,3,4,4a,5,6a,12,12a,12b-decahydro-4-((acetyloxy)methyl)-3,6-bis(acetyloxy)-12-hydroxy-9-(3-pyridinyl)-4,6a,12b -trimethyl-

CAS 147444-03-9 MFCD00929109

化学结构图

147444-03-9
SMILES: C[C@]12CC[C@H](OC(C)=O)[C@@](C)(COC(C)=O)[C@@H]1C[C@H](OC(C)=O)[C@@]1(C)OC3C=C(OC(=O)C=3[C@H](O)[C@H]21)C1=CC=CN=C1

化学属性

Mol. FormulaC31H37NO10
Mol. Weight583.69

别名和识别编码

Chemical Name2H,11H-Naphtho(2,1-b)pyrano(3,4-e)pyran-11-one,1,3,4,4a,5,6a,12,12a,12b-decahydro-4-((acetyloxy)methyl)-3,6-bis(acetyloxy)-12-hydroxy-9-(3-pyridinyl)-4,6a,12b -trimethyl-
Synonym Pyripyropene A
CAS Number147444-03-9
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相关文献及参考

  • [2]. Ohtawa M, et al. Design and Synthesis of A-Ring Simplified Pyripyropene A Analogues as Potent and Selective Synthetic SOAT2 Inhibitors. ChemMedChem. 2018 Mar 6;13(5):411-421.
  • [3]. Ohshiro T, et al. Pyripyropene A, an acyl-coenzyme A:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia. Arterioscler Thromb Vasc Biol. 2011 May;31(5):1108-15.
  • [4]. Lee KR , et al. Determination of Penicillium griseofulvum-oriented pyripyropene A, a selective inhibitor of acyl-coenzyme A:cholesterol acyltransferase 2, in mouse plasma using liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic studies. Biomed Chromatogr. 2019 Feb;33(2):e4388.
  • [1]. Hayashi A, et al. Pyripyropenes, fungal sesquiterpenes conjugated with alpha-pyrone and pyridine moieties, exhibits anti-angiogenic activity against human umbilical vein endothelial cells. Biol Pharm Bull. 200

安全信息

RTECSQL6289000 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 47,148,1994

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Acyltransferase  (酰基转移酶)

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