Licofelone 2-[2-(4-氯苯基)-6,6-二甲基-1-苯基-5,7-二氢吡咯烷嗪-3-基]乙酸
CAS 156897-06-2 MFCD00929900
化学结构图
SMILES: CC1(C)CC2=C(C(C3C=CC(Cl)=CC=3)=C(CC(O)=O)N2C1)C1C=CC=CC=1
化学属性
| Mol. Formula | C23H22ClNO2 |
|---|---|
| Mol. Weight | 380 |
别名和识别编码
| Chemical Name | Licofelone |
|---|---|
| CAS Number | 156897-06-2 |
| Synonym | 6-(4-Chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl- 2,2-Dimethyl-6-(4-chlorophenyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl)acetic acid ML 3000 2,3-Dihydro-6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-1H-pyrrolizine-5-acetic acid |
| Chemical Name Translation | 2-[2-(4-氯苯基)-6,6-二甲基-1-苯基-5,7-二氢吡咯烷嗪-3-基]乙酸 |
| Beilstein Registry Number | 6823674 |
| MDL Number |
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分类
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- Dual inhibitor of cyclooxygenase and 5-lipoxygenase. Anti-inflammatory.
相关文献及参考
- [2]. Alvaro-Gracia JM, et al. Licofelone--clinical update on a novel LOX/COX inhibitor for the treatment of osteoarthritis. Rheumatology (Oxford). 2004 Feb;43 Suppl 1:i21-5.
- [3]. Laufer SA, et al. (6,7-Diaryldihydropyrrolizin-5-yl)acetic acids, a novel class of potent dual inhibitors of both cyclooxygenase and 5-lipoxygenase. J Med Chem. 1994 Jun 10;37(12):1894-7.
- Laufer, S.A., et al.: J. Med. Chem., 37, 1894 (1994),
- Moreau, M., et al.: J. Vet. Pharmacol. Ther., 28, 81 (2005),
- Tries, S., et al.: Inflamm. Res., 51, 135 (2002),
- [1]. Tavolari S, et al. Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently f
- [1]. Tavolari S, et al. Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade. Carcinogenesis. 2008 Feb;29(2):371-80.
安全信息
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 45,159,1995
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