2-(furan-2-yl)-7-phenethyl-6,7-dihydro-5H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-imine 2-(呋喃-2-基)-7-苯乙基-7H-吡唑并[4,3-e][1,2,4]三唑并[1,5-c]嘧啶-5-胺

CAS 160098-96-4 MFCD00933778

化学结构图

160098-96-4
SMILES: NC1=NC2=C(C=NN2CCC2C=CC=CC=2)C2=NC(=NN21)C1=CC=CO1

化学属性

Mol. FormulaC18H15N7O
Mol. Weight345.36

别名和识别编码

Chemical Name2-(furan-2-yl)-7-phenethyl-6,7-dihydro-5H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-imine
Synonym 7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine SCH 58261
MDL NumberMFCD00933778
PubChem Substance ID329824547
Chemical Name Translation2-(呋喃-2-基)-7-苯乙基-7H-吡唑并[4,3-e][1,2,4]三唑并[1,5-c]嘧啶-5-胺
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分类

  • {SNA} Adenosines/P2 Nucleotide Receptor - Antagonists, Adenosines/P2 Nucleotide Receptors (Purinergics), Antagonists, Bioactive Small Molecule Alphabetical Index, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience,
  • {SNA} Adenosines/P2 Nucleotide Receptor - Antagonists, Adenosines/P2 Nucleotide Receptors (Purinergics), Antagonists, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, Proteins and Derivatives, S
  • {SNA

相关文献及参考

  • [2]. Varani K, et al. Pharmacological and biochemical characterization of purified A2a adenosine receptors in human platelet membranes by [3H]-CGS 21680 binding. Br J Pharmacol. 1996 Apr;117(8):1693-701.
  • [3]. Xi J, et al. Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts. J Mol Cell Cardiol. 2009 Nov;47(5):684-90.
  • [4]. Kuzumaki N, et al. Multiple analyses of G-protein coupled receptor (GPCR) expression in the development of gefitinib-resistance in transforming non-small-cell lung cancer. PLoS One. 2012;7(10):e44368.
  • [5]. Mediavilla-Varela M, et al. Antagonism of adenosine A2A receptor expressed by lung adenocarcinoma tumor cells and cancer associated fibroblasts inhibits their growth. Cancer Biol Ther. 2013 Sep;14(9):860-8.
  • [6]. Wardas J, et al. SCH 58261, a selective adenosine A2A receptor antagonist, decreases the haloperidol-enhanced proenkephalin mRNA expression i

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Proteins and Derivatives - Biochemicals and Reagents
  4. Membrane Protein Biology Tools - Proteins and Derivatives
  5. GPCR Proteins, Modulators and Antibodies - Membrane Protein Biology Tools
  6. GPCR Modulators - GPCR Proteins, Modulators and Antibodies
  7. Adenosines/P2 Nucleotide Receptor - Antagonists - GPCR Modulators
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Adenosine Receptor  (腺苷受体)

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