Avasimibe 2,6-二异丙基苯基(2-(2,4,6-三异丙基苯基)乙酰基)氨基磺酸酯
CAS 166518-60-1 MFCD00934956
化学结构图
SMILES: CC(C)c1cc(C(C)C)c(CC(=O)NS(=O)(=O)Oc2c(C(C)C)cccc2C(C)C)c(C(C)C)c1
化学属性
| Mol. Formula | C29H43NO4S |
|---|---|
| Mol. Weight | 501.72 |
别名和识别编码
| Chemical Name | Avasimibe |
|---|---|
| Synonym | ((2,4,6-Tris(1-methylethyl)phenyl)acetyl)sulfamic acid 2,6-bis(1-methylethyl)phenyl ((2,4,6-tris(1-methylethyl)phenyl)acetyl)sulfamate Avasimibe CI 1011 CI-1011 CI-1011; PD 148515; [[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl)phenyl ester] sulfamic acid N-((2,6-Bis(1-methylethyl)phenoxy)sulfonyl)-2,4,6-tris(1-methylethyl)benzeneacetamide avasimibe avasimibe sodium |
| MDL Number | MFCD00934956 |
| CAS Number | 166518-60-1 |
| Chemical Name Translation | 2,6-二异丙基苯基(2-(2,4,6-三异丙基苯基)乙酰基)氨基磺酸酯 |
| PubChem Substance ID | 166558 |
| InChI | InChI=1S/C29H43NO4S/c1-17(2)22-14-25(20(7)8)27(26(15-22)21(9)10)16-28(31)30-35(32,33)34-29-23(18(3)4)12-11-13-24(29)19(5)6/h11-15,17-21H,16H2,1-10H3,(H,30,31) |
| LabNetwork Molecule ID | LN01281678 |
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分类
- {SNA} AN-AZ, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cholesterol and Cholesterol Metabolism, Lipids in Cell Signaling, Pfizer Compounds, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- {SNA} AN-AZ, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules,
相关文献及参考
- [2]. Raal FJ et al. Avasimibe, an ACAT inhibitor, enhances the lipid lowering effect of atorvastatin in subjects with homozygousfamilial hypercholesterolemia. Atherosclerosis, 2003 Dec, 171(2):273-9.
- [3]. Delsing DJ et al. Acyl-CoA:cholesterol acyltransferase inhibitor avasimibe reduces atherosclerosis in addition to its cholesterol-lowering effect in ApoE*3-Leiden mice. Circulation, 2001 Apr 3, 103(13):1778-86.
- [1]. Tardif JC et al. Effects of the acyl coenzyme A:cholesterol acyltransferase inhibitor avasimibe on human atherosclerotic lesions. Circulation, 2004 Nov 23, 110(21):3372-7.
- [1]. Tardif JC et al. Effects of the acyl coenzyme A:cholesterol acyltransferase inhibitor avasimibe on human atherosclerotic lesions. Circulation, 2004 Nov 23, 110(21):3372-7.
- [2]. Raal FJ et al. Avasimibe, an ACAT inhibitor, enhances the lipid lowering effect of atorvastatin in subjects with homozygousfamilial hypercholesterolemia. Atherosclerosis, 2003 De
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