Fingolimod Hydrochloride 2-氨基-2-(4-辛基苯乙基)-1,3-丙二醇盐酸盐
CAS 162359-56-0 MFCD00939512
化学结构图
SMILES: Cl.CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1
化学属性
| Mol. Formula | C19H34ClNO2 |
|---|---|
| Mol. Weight | 344 |
| Melting Point | 102-107 |
别名和识别编码
| Chemical Name | Fingolimod Hydrochloride |
|---|---|
| CAS Number | 162359-56-0 |
| Synonym | 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-diol hydrochloride FTY720 |
| MDL Number | MFCD00939512 |
| Chemical Name Translation | 2-氨基-2-(4-辛基苯乙基)-1,3-丙二醇盐酸盐 |
| Beilstein Registry Number | 7837310 |
| Reaxys-RN | 7837310 |
| Merck Number | 4083 |
| PubChem Substance ID | 253660828 |
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信息真实价格透明
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分类
- Aromatics
- Inhibitors
- Metabolites & Impurities
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
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相关文献及参考
- [2]. Coldewey SM, et al. Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis. Sci Rep. 2016 Jun 9;6:27594.
- [3]. Cipriani R, et al. FTY720 attenuates excitotoxicity and neuroinflammation. J Neuroinflammation. 2015 May 8;12:86.
- [4]. Arielle M Bryan, et al. Sphingosine-1-phosphate receptors and innate immunity. Cell Microbiol. 2018 May;20(5):e12836.
- Brinkmann, V., et al.: Transplantation, 72, 764 (2001),
- Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002),
- Mtaloubian, M., et al.: Nature, 427, 355 (2004),
- [1]. Rolin J, et al. FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and
- [1]. Rolin J, et al. FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release. Cancer Immunol Immunother. 2010, 59(4), 575-586.
安全信息
GHS Symbol
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R52/53
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P312+P330
- P308+P313
- P338 Remove contact lenses, if present and easy to do. Continue rinsing. 如果戴隐形眼睛并容易摘掉的话，取出隐形眼镜，继续冲洗。
- P351 Rinse cautiously with water for several minutes. 小心地用水冲洗几分钟。
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H302 Harmful if swallowed 吞食有害
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