Fosaprepitant 福沙吡坦
CAS 172673-20-0 MFCD00942401
化学结构图
SMILES: C[C@@H](O[C@H]1OCCN(CC2NC(=O)N(N=2)P(O)(O)=O)[C@H]1C1=CC=C(F)C=C1)C1C=C(C=C(C=1)C(F)(F)F)C(F)(F)F
化学属性
| Mol. Formula | C23H22F7N4O6P |
|---|---|
| Mol. Weight | 614.41 |
别名和识别编码
| Chemical Name | Fosaprepitant |
|---|---|
| CAS Number | 172673-20-0 |
| Synonym | P-[3-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonic Acid L 758298 |
| Chemical Name Translation | 福沙吡坦 |
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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分类
- Aromatics
- Chiral Reagents
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Phosphorylating and Phosphitylating Agents
产品应用
- Fosaprepitant is a selective neurokinin-1 (NK-1) receptor antahonist. Fosaprepitant is an antiemetic drug, a Aprepitant (A729800) prodrug.
相关文献及参考
- Cocquyt, V., et al.: Eur. J. Canc., 37, 835 (2001),
- Tattersall, F., et al.: Neuropharmacol., 39, 652 (2000),
- [1]. Pranav Prasoon, et al. Role of fosaprepitant, a neurokinin Type 1 receptor antagonist, in morphine-induced antinociception in rats. Indian J Pharmacol. 2016 Jul-Aug; 48(4): 394-398.
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