Conivaptan HCl 盐酸考尼伐坦

CAS 168626-94-6 MFCD00945712

化学结构图

168626-94-6
SMILES: Cl.CC1NC2C3=CC=CC=C3N(CCC=2N=1)C(=O)C1C=CC(=CC=1)NC(=O)C1C=CC=CC=1C1C=CC=CC=1

化学属性

Mol. FormulaC32H27ClN4O2
Mol. Weight535.04

别名和识别编码

Chemical NameConivaptan HCl
CAS Number168626-94-6
Synonym N-[4-[(4,5-Dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-[1,1'-Biphenyl]-2-carboxamide Hydrochloride Vaprisol YM 087
Chemical Name Translation盐酸考尼伐坦
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分类

  • Aromatics
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Used in treatment of congestive heart failure.

相关文献及参考

  • [2]. Fernandez-Varo G, et al. Effect of the V1a/V2-AVP receptor antagonist, Conivaptan, on renal water metabolism and systemic hemodynamics in rats with cirrhosis and ascites. J Hepatol. 2003 Jun;38(6):755-61.
  • [3]. Yatsu T, et al. Cardiovascular and renal effects of conivaptan hydrochloride (YM087), a vasopressin V1A and V2 receptor antagonist, in dogs with pacing-induced congestive heart failure. Eur J Pharmacol. 1999 Jul 9;376(3):239-46.
  • Arai, Y., et al.: J. Pharm. Sci., 109, 53 (2009),
  • Mao, Z., et al.: Clin. Ther., 31, 1542 (2009),
  • [1]. Wada K, et al. Intravenous administration of conivaptan hydrochloride improves cardiac hemodynamics in rats with myocardial infarction-induced congestive heart failure.
  • [1]. Wada K, et al. Intravenous administration of conivaptan hydrochloride improves cardiac hemodynamics in rats with myocardial infarction-induced congestive heart failure. Eur J Pharmacol. 2005 Jan 10;507(1-3):145-51. Epub 2005 Jan 1.

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Vasopressin Receptor  (血管加压素受体)

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