Darusentan (S)-2-((4,6-二甲氧基嘧啶-2-基)氧基)-3-甲氧基-3,3-二苯基丙酸

CAS 171714-84-4 MFCD00949063

化学结构图

171714-84-4
SMILES: COC1C=C(N=C(N=1)O[C@H](C(O)=O)C(OC)(C1C=CC=CC=1)C1C=CC=CC=1)OC

化学属性

Mol. FormulaC22H22N2O6
Mol. Weight410.424

别名和识别编码

Chemical NameDarusentan
Chemical Name Translation(S)-2-((4,6-二甲氧基嘧啶-2-基)氧基)-3-甲氧基-3,3-二苯基丙酸
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相关文献及参考

  • [2]. Liang F, et al. Darusentan is a potent inhibitor of endothelin signaling and function in both large and small arteries. Can J Physiol Pharmacol. 2010 Aug;88(8):840-9.
  • [3]. H H Dao, et al. Norepinephrine-induced aortic hyperplasia and extracellular matrix deposition are endothelin-dependent. J Hypertens. 2001 Nov;19(11):1965-73.
  • [1]. Frank Enseleit, et al. Darusentan, a selective endothelin A receptor antagonist, for the oral treatment of resistant hypertension. Ther Adv Cardiovasc Dis. 2010 Aug;4(4):231-40.
  • [1]. Frank Enseleit, et al. Darusentan, a selective endothelin A receptor antagonist, for the oral treatment of resistant hypertension. Ther Adv Cardiovasc Dis. 2010 Aug;4(4):231-40.
  • [2]. Liang F, et al. Darusentan is a potent inhibitor of endothelin signaling and function in both large and small arteries. Can J Physiol Pharmacol. 2010 Aug;88(8):840-9.
  • [3]. H H Dao, et al. Norepinephrine-induced aortic hyperplasia and extrace

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Endothelin Receptor  (内皮素受体)

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