Tipranavir N-(3-((R)-1-((R)-4-羟基-2-氧代-6-苯乙基-6-丙基-5,6-二氢-2H-吡喃-3-基)丙基)苯基)-5-(三氟甲基)吡啶-2-磺酰胺

CAS 174484-41-4 MFCD00949098

化学结构图

174484-41-4
SMILES: CC[C@@H](C1=C(O)C[C@@](CCC)(CCC2C=CC=CC=2)OC1=O)C1=CC(=CC=C1)NS(=O)(=O)C1C=CC(=CN=1)C(F)(F)F

化学属性

Mol. FormulaC31H33F3N2O5S
Mol. Weight602.66

别名和识别编码

Chemical NameTipranavir
CAS Number174484-41-4
Synonym N-[3-[(1R)-1-[(6R)-5,6-Dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-pyran-3-yl]propyl]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide
Chemical Name TranslationN-(3-((R)-1-((R)-4-羟基-2-氧代-6-苯乙基-6-丙基-5,6-二氢-2H-吡喃-3-基)丙基)苯基)-5-(三氟甲基)吡啶-2-磺酰胺
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • Inhibitors
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • Nonpeptidic HIV protease inhibitor (NPPI). Antiviral.

相关文献及参考

  • [2]. Li F, et al. Metabolism-mediated drug interactions associated with ritonavir-boosted tipranavir in mice. Drug Metab Dispos. 2010 May;38(5):871-8.
  • [3]. Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6(1):212.
  • Boffito, M., et al.: J. Clin. Pharmacol., 46, 130 (2006),
  • McGregor, T.R., et al.: HIV Clin. Trials, 5, 371 (2004),
  • Poppe, S.M., et al.: Antimicrob. Agents Chemother., 41, 1058 (1997),
  • [1]. Aoki M, et al. Loss of the protease dimerization inhibition activity of tipranavir (TPV) and its association with the acquisition of resistance to TPV by HIV-1. J Virol. 2012 Dec;86(24):13384-96.
  • [1]. Aoki M, et al. Loss of the protease dimerization inhibition activity of tipranavir (TPV) and its association with the acquisition of resistance to TPV by HIV-1. J Virol. 2012 Dec;86(24):13384-96.
  • {

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. HIV Protease  (HIV蛋白酶)

相关产品推荐